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CHIP - Maybe it's not the TKIs?

Started by kat73 , Jan 31 2018 11:55 AM

cardiovascular effects

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2 replies to this topic

#1 kat73

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LocationWashington, DC area

Posted 31 January 2018 - 11:55 AM

This may be my last post, I don't know, but I wanted to get this in before we all scatter to the four winds.

Did anyone see the NY Times article on Monday, Jan. 29th, Scientists Discover a Bone-Deep Risk for Heart Disease, by Gina Kolata? About a hematopoetic stem cell mutation called CHIP strongly associated with cardiovascular disease? It makes me wonder: maybe the cardiovascular disease side effects and/or adverse events that are starting to show up with some longterm TKI use are really not the fault of the TKIs after all, but rather of the Big Mama hematopoetic stem cell (which our TKIs don't reach) having this CHIP mutation, right along with the one that says, "leukemia, go forth and multiply."

It's just a thought. Seems there would be some logic behind it.

Dx July 2009 on routine physical. WBC 94. Started Gleevec 400 mg Sept 2009. MMR at 2yrs. Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved. Kidney issues developed because of Gleevec. Switched to Sprycel 70 mg in Aug 2011. Above side effects disappeared or improved. Have been MR3.5 - 4.5 ever since. Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017. After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS. Pleural effusion returned within a couple of months, same as before (moderate, left side only). Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved. At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.

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#2 Red Cross Kirk

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LocationOregon

Posted 31 January 2018 - 12:08 PM

I too thought briefly about that article and wondered if there could be a connection. Haven't had much time lately to research it yet.

Kirk

9/25/2012 p210 transcript 118.7% IS @ D_x, begin Gleevec 400mg/day

12/2012 3.59% & bone marrow biopsy - no residual myeloproliferative features but detected 1/20 metaphases containing the Philadelphia chromosome

2013 0.914%, 0.434%, 0.412%

10/2013 0.360% & bone marrow biopsy - normal male karyotype with no evidence of a clonal cytogenetic abnormaltiy

2014 0.174%, 0.088%, 0.064%

2015 0.049%, decrease to Gleevec 200mg/day, 0.035%, 0.061%, 0.028%

2016 0.041%, 0.039%, 0.025%

2017 0.029%, 0.039%, switched to generic imatinib 200mg/day, 0.070%, 0.088%

2018 0.233%

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#3 scuba

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LocationHouston, Texas

Posted 31 January 2018 - 01:58 PM

Fascinating article ....

"For now, doctors advise against testing for CHIP, since there is nothing specific to be done to reduce the increased risks of cancer or heart disease that it confers.

But, he said, if people really want to know if they have CHIP, they can get a blood test that costs a few thousand dollars. (If there is no particular reason for the test, insurance may not pay.)

Dr. Steensma said that if he had CHIP, he would make sure he did his best to control all of his heart disease risks, like cholesterol and blood pressure, and that he had a healthy diet and exercised. Drugs may be developed to help stem the inflammation in arteries, he added.

As for the cancer risk, Dr. Ross Levine at Memorial Sloan Kettering Cancer Center just opened a C.H.I.P clinic in part to explore whether some patients with CHIP have a greater risk of blood cancers, and if so, what to do about it."

Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale)

March 2017 PCR: 0.01% (M.D. Anderson scale)

June 2017 PCR: "undetected"

September 2017 PCR: "undetected"