and I'm scared and losing sleep on it...
Long story short: Reduced Gleevec dosage from 400mg to 300mg about 9 months ago. Still undetected at the end of Oct 2017. Here comes Jan., my PCR jumped to 0.33% IS . From undetected to losing MMR in about 10 weeks!?
Some more details: Dx Dec 2013. Started 400mg Gleevec. Very quickly, went in and out of undetected between Jun-Dec 2014. Then, undetected for more than 2 years and convinced Dr to reduced dosage to 300mg in March 2017. June 2017 got 0.0002% IS. Dr wanted to get back to 400mg immediately, but I held off. Retested in July and Oct 2017; both came back negative while staying on 300mg. Just got the Jan 2018 report of 0.33%!! Again, Dr wants me to go back to 400mg. I will definitely go for a retest as soon as I can, but in the mean time, not sure if I want to go back to 400mg or to stick with 300mg.
My white cell count and red cell count had always been a little below normal since treatment. Co-incidentally, I got a completely normal CBC in Jan. Not sure if it is a bad or good indication of the dosage reduction.
The logical side of me is convinced the PCR jump is a lab error; however, the emotional side is keeping me awake at night. What if the test is right? No longer MMR? What if PCR doesn't come back down if I delay getting back on 400mg?
Last time when I asked for a retest, she told me I have to wait a month between each PCR test. Not sure if it is more of an insurance issue than a medical guideline. Either way, it's going to be a long month...