5 replies to this topic

[scuba]

Dasatinib increases endothelial permeability leading to pleural effusion

http://erj.ersjourna...nt/51/1/1701096

[JohnFromChicago]

Dasatinib increases endothelial permeability leading to pleural effusion

http://erj.ersjourna...nt/51/1/1701096

 

 

Interesting. I wonder why some of us seem to be much more prone to these than others.

[kat73]

Wow, interesting.  Dr. Mauro's slide presentation listed the endothelial thingie as a possible cause for pleural effusion, along with all the cardiovascular stuff as well.  I would love a translation into layspeak of the mechanism outlined in the abstract.  The gist I got is the dasatinib makes holes in certain cells and they fill up with fluid.  Close?

[scuba]

Interesting. I wonder why some of us seem to be much more prone to these than others.

 

from the abstract,

 

"Interestingly, we demonstrated that this increased endothelial permeability is a reactive oxygen species (ROS)-dependent mechanism in vitro and in vivo using a cotreatment with an antioxidant agent, N-acetylcysteine."

 

ROS is what is created during energy production in the mitochondria. "Anti-oxidants" remove ROS. This is why you hear the phrase eat more 'anti-oxidant' rich food such as blueberries:

 

https://www.webmd.co...0-super-foods#2

 

It would be interesting to learn that those of us who eat anti-oxidant foods and take Sprycel are less likely to develop pleural effusions than those who don't. That would be an interesting study.

 

In the mean time, Kat - perhaps increasing your intake of foods listed in the link above may prove helpful in reducing further pleural effusion risk. In my own case, I eat a lot of blueberries (daily for the most part) along with handful of nuts every day (almonds/walnuts mostly). 

[JohnFromChicago]

from the abstract,

 

"Interestingly, we demonstrated that this increased endothelial permeability is a reactive oxygen species (ROS)-dependent mechanism in vitro and in vivo using a cotreatment with an antioxidant agent, N-acetylcysteine."

 

ROS is what is created during energy production in the mitochondria. "Anti-oxidants" remove ROS. This is why you hear the phrase eat more 'anti-oxidant' rich food such as blueberries:

 

https://www.webmd.co...0-super-foods#2

 

It would be interesting to learn that those of us who eat anti-oxidant foods and take Sprycel are less likely to develop pleural effusions than those who don't. That would be an interesting study.

 

In the mean time, Kat - perhaps increasing your intake of foods listed in the link above may prove helpful in reducing further pleural effusion risk. In my own case, I eat a lot of blueberries (daily for the most part) along with handful of nuts every day (almonds/walnuts mostly). 

 

27 Months on 100mg Sprycel, no PE. Consume brazil nuts daily which have good amounts of selenium (antioxidant). I guess I wont stop eating those any time soon.

[kat73]

Scuba - I eat almost all of those foods, consistently, and always have (at least since being a conscientious adult), as I like them.  Although it certainly can't hurt to eat this way, I suspect that if there is a counter-action like dasatinib at the cellular level it might not make any difference to eat more.  But thank you.

 

JohnFromChicago - I had absolutely NO symptoms with my first two pleural effusions; they were found by accident on chest x-rays I had for other purposes.  I complained only for the third one and they went actively looking for it (again, chest x-ray), and there it was.  Only by the fourth one did I begin to pick up on whether I had one or not. At the very worst, all I had was continuing fatigue with exercise, a very slight nagging dry cough when lying flat (like at night), and a feeling of fullness or tightness at the bottom of my ribs, sort of midriff-ish, waist-ish.  My guess is more people have them than know they do.  I'm a little worried right now, as a matter of fact, after being back on Sprycel 50 mg for 3 weeks because I possibly lost CCyR.