Posted 13 January 2018 - 08:08 AM
I know that I cannot have any grapefruit juice, which is a strong inhibitor of CYP3A4, is taboo for me. I think the same holds true for Sprycel and Gleevec. Taking an inhibitor reduces the metabolism of Tasigna, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. The result: too much drug in your body. i.e. overdose. Inducers have the opposite effect. Read the prescribing info on your TKI carefully. I think you'll find that you want to stay away from this.
Dx 9/26/16 WBC 28800; platelets 749; FISH 97% PCR 43%
Tasigna 600MG per day
October 2016 PCR 22% IS
November 2016 PCR 5.8% IS
December 2016 PCR 0.1% IS MMR!!
March 10, 2017 PCR 0.006% IS MR 4.22
Tasigna 450MG per day
April 5, 2017 PCR <.003% IS
June 5, 2017 PCR <.003% IS (dose reduction validated!!!)
Tasigna 300MG per day starting June 15, 2017
6-day drug break starting June 20, 2017 due to multiple AE's
July 24, 2017 PCR <.003% IS
September 18, 2017 Negative, AKA PCRU
Tasigna 150mg per day starting 9/18/17
October 30, 2017 Negative
December 11, 2017 Negative