Posted 31 December 2017 - 06:42 PM
I was originally on 400mg of Gleevec but now on 200mg of imatinib after reducing from 300mg. My PCR has gone up over the last few tests (every 4 months) up but still quite low. I reduced from 300 to 200mg on my own recently as I was feeling very fatigued
I also reduced to 200mg Gleevec on my own, whilst it did seem to improve things a little, it certainly wasn't enough improvement for me, and within one test (3 months) my PCR crept from .002 to .005 - probably nothing to be concerned about and maybe not a trend, but my eventual goal is to try cessation, and this looked unlikely to help long term.
I was scared of switching, but in hindsight, it was a brilliant decision for me (so far!). It has dramatically improved my quality of life. If I was running at about 30% of my capacity and quality of life on Gleevec 200mg, I feel like I am at 85% on Tasigna 600mg. I am capable of much more exercise, I have added weights to my regime, and I don't notice any fatigue at all in comparison to Gleevec.
I can't even imagine how I'll feel if I get to reduce it or stop. Which is my goal, I don't particularly want or think I need to be on this dosage long term.
Diagnosed 9 June 2011, Glivec 400mg June 2011-July 2017, Tasigna 600mg July 2017-present (switched due to intolerable side effects, and desire for future cessation attempt).
Commenced monthly testing when MR4.0 lost during 2012.
2017: <0.01, <0.01, 0.005 (200mg Glivec, Adelaide) <0.01, 0.001 (new test sensitivity)
2016: <0.01, <0.01, PCRU, 0.002 (Adelaide)
2015: <0.01, <0.01, <0.01, 0.013
2014: PCRU, <0.01, <0.01, <0.01, <0.01
2013: 0.01, 0.014, 0.016, 0.026, 0.041, <0.01, <0.01
2012: <0.01, <0.01, 0.013, 0.032, 0.021
2011: 38.00, 12.00, 0.14