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Arterial Thrombotic Events Associated With First-line Nilotinib for CML in Older Adults

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#1 gerry


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Posted 22 December 2017 - 07:33 PM


#2 cmljax


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Posted 23 December 2017 - 08:21 AM

This study doesn't appear to stratify those experiencing ATE's by whether or not they had other predispositions, e.g. high cholesterol, high blood pressure; weight, etc. nor does it appear to provide data based on dose of Tasigna, so I guess the assumption is that all 345 were on 600 mg???


Regardless, this is yet another in a line of studies showing that Tasigna causes ATE's. In my case so far, Tasigna has caused me to have premature atrial contractions, a so far benign heart arrhythmia that continues even on the low dose (150 mg) I am taking.  Here's hoping I can stay at MR 4.5 or better for another year and then my oncologist will supervise a cessation attempt for me.


Would like to hear of others on this site on Tasigna who have experienced ATE's.

Dx 9/26/16 WBC 28800; platelets 749; FISH 97% PCR 43%

Tasigna 600MG per day

October 2016                     PCR 22% IS

November 2016                 PCR 5.8% IS

December 2016                 PCR 0.1% IS  MMR!!

March 10, 2017                 PCR 0.006% IS  MR 4.22

Tasigna 450MG per day

April 5, 2017                      PCR <.003% IS

June 5, 2017                     PCR <.003% IS (dose reduction validated!!!)

Tasigna 300MG per day starting June 15, 2017

6-day drug break starting June 20, 2017 due to multiple AE's

July 24, 2017                     PCR <.003% IS

September 18, 2017          Negative, AKA PCRU

Tasigna 150mg per day starting 9/18/17

October 30, 2017               Negative

December 11, 2017           Negative

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