Member
Posted 06 December 2017 - 12:36 PM
I was diagoned on 11/11/13 with slightly elevated blood counts . Started taking Glevec 400 mg from 19/11 . Initial response was very good . I went to 0.000 after an year . But I become detectable in 2015 with 0.0005 in IS and kept hoovering around those levels till my last test . The last one shows 0.005 . Doctor is not worried . Is it an early sign of loosing response ? I was under on an antimalaria ( doxycycline antibiotic ) drug in in October-November
Thanks
Advanced Member
Posted 06 December 2017 - 12:43 PM
Thomas -
Any PCR measurement below 0.01% IS is almost - and some report is - indistinguishable from PCRU. You are not losing response.
Your current readings are in the 'noise' of the test. A perfectly healthy person with no history of CML could get readings at the levels you reported.
What is important is trend and only if your PCR starts to test above 0.01. Should that happen, you would have monthly PCR tests to verify a trend upward.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
Advanced Member
Posted 09 January 2018 - 04:06 PM
Hi, Thomas.
Probably just the noise of the test or some interaction with the antibiotic. Still a great number. It will probably trend down next text.
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