Interesting article I stumbled upon...
https://www.news-med...tudy-shows.aspx
Interesting Article - TKI with PGE1
Started by
JohnFromChicago
, Dec 05 2017 11:14 PM
8 replies to this topic
#1
JohnFromChicago
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Posted 05 December 2017 - 11:14 PM
Diagnosed Age: 28
Diagnosed Date: Oct-20-2015
0-27 Months Rx: Sprycel 100mg
Current Rx: Sprycel 50mg
0 Month PCR = 87%
3 Month PCR = 1.2%
6 Month PCR = 0.64%
9 Month PCR = 0.26%
12 Month PCR = 0.21%
15 Month PCR = 0.15%
18 Month PCR = 0.11%
21 Month PCR = 0.05%
24 Month PCR = 0.04%
27 Month PCR = 0.01%
#2
thatguy
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Posted 05 December 2017 - 11:45 PM
Good stuff!
3/25/2015- Dx'ed by FISH : 85% of cells dual-fusion signals, 7% with tri-fusion signals, WBC 212,000. Started Gleevec 400mg.... Calculated .93 SOKAL
08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)
08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)
#3
Trey
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Posted 06 December 2017 - 10:14 AM
A better title for the article would read: "Erectile dysfunction drug cures CML". Film at eleven.
#4
r06ue1
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Posted 06 December 2017 - 11:24 AM
A better title for the article would read: "Erectile dysfunction drug cures CML". Film at eleven.
Bonus! 
The second drug (Misoprostol) does not appear to be good for women: https://www.drugs.co...isoprostol.html
Too bad we can't conduct our own trial, since the drugs are already available by prescription. 
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
#5
scuba
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Posted 06 December 2017 - 11:31 AM
59th Annual Meeting and Exposition (December 9-12, 2017)
You may search for particular presentations by typing key words, an author's name, or the title in the box below. You may specify the type of search, i.e. whether you want to see pages that contain any or all of the words you specify. The Boolean search option requires one of the keywords and, or, and not, as well as parentheses.
The search filters will allow you to restrict your search by date, session type, or abstract category and are all optional. Hold down the Ctrl key while selecting to choose more than one option in each list, or hold down the Shift key to select a range.
Search: PGE1 All words Any word Boolean
Restrict search results to:
Date
No Restriction Thursday, December 7, 2017 Friday, December 8, 2017 Saturday, December 9, 2017 Sunday, December 10, 2017 Monday, December 11, 2017 Tuesday, December 12, 2017
No Restriction Thursday, December 7, 2017 Friday, December 8, 2017 Saturday, December 9, 2017 Sunday, December 10, 2017 Monday, December 11, 2017 Tuesday, December 12, 2017
Session Type
Oral Poster
Oral Poster
Found 0 matches
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
#6
JohnFromChicago
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Posted 08 December 2017 - 04:42 PM
Bonus!
The second drug (Misoprostol) does not appear to be good for women: https://www.drugs.co...isoprostol.html
Too bad we can't conduct our own trial, since the drugs are already available by prescription.
Well PGE1 (Alprostadil) can be bought over the counter in Mexico so someone living there could try this. I can't see any risk for someone trying this since there are no interactions between Alprostadil and Sprycel. Even if it didn't go as far as to eradicate the stems cell immediate PCRU from one injection of a proven safe OTC medicine would make many of us waiting in/around MMR on here ecstatic. My guess is if it did work at all, it would only work for a subset of us for unknown reasons but who knows.
Diagnosed Age: 28
Diagnosed Date: Oct-20-2015
0-27 Months Rx: Sprycel 100mg
Current Rx: Sprycel 50mg
0 Month PCR = 87%
3 Month PCR = 1.2%
6 Month PCR = 0.64%
9 Month PCR = 0.26%
12 Month PCR = 0.21%
15 Month PCR = 0.15%
18 Month PCR = 0.11%
21 Month PCR = 0.05%
24 Month PCR = 0.04%
27 Month PCR = 0.01%
#7
TeddyB
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Posted 09 December 2017 - 04:10 AM
No risk?
"This medicine is given as a shot into your penis."
#8
JohnFromChicago
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Posted 11 December 2017 - 11:26 AM
No risk?
"This medicine is given as a shot into your penis."
Ohh Wow! I would think for purposes of treating CML it would be just as effective if given in the arm...or at least I would hope haha.
Diagnosed Age: 28
Diagnosed Date: Oct-20-2015
0-27 Months Rx: Sprycel 100mg
Current Rx: Sprycel 50mg
0 Month PCR = 87%
3 Month PCR = 1.2%
6 Month PCR = 0.64%
9 Month PCR = 0.26%
12 Month PCR = 0.21%
15 Month PCR = 0.15%
18 Month PCR = 0.11%
21 Month PCR = 0.05%
24 Month PCR = 0.04%
27 Month PCR = 0.01%
#9
TeddyB
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Posted 11 December 2017 - 12:23 PM
Ohh Wow! I would think for purposes of treating CML it would be just as effective if given in the arm...or at least I would hope haha.
That would be a big plus 
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