23 and Me Ancestry Kit
Posted 02 December 2017 - 04:12 PM
I just ordered a 23 and Me kit for the purpose of determining my ancestry. Was wondering if my CML would skew the results. I did ask them and they said as long as my white blood cell count is normal, their shouldn't be an issue. Then I asked them if the fact the only reason it's normal is because I'm on medication to control it..... Tasigna. They couldn't answer me.
Has anyone here taken one of these ancestry type tests while on Tasigna? If there's any doubt about the results due to my CML, I would just as soon give the kit to another sibling.
I've heard the cons about this technology. I'm 67 and on Medicare. So they can do whatever they want with my results. Every technology has a pro and a con. I'm an optimist.
Posted 02 December 2017 - 11:14 PM
Never once was there a question about wbc or any other counts being normal. I'm panocytopenic (all blood counts low) and it didn't appear to have any effect on results.
I've also done the Ancestry.com one. The two are comparable, but Ancestry's data base is much larger. I've been doing ancestry as a hobby for 10 years and to be honest I don't find the DNA part of it very helpful because you still need to research and verify sources. It does help you connect to relatives you may not know though.
Hope this helps you.
CyCR - Aug 2014, Positive for 1 chromosome Sep 2015. PCR: 12.77 in Oct, 2012 to 0.04 (MDA) in Mar, 2016. 4/2016 - 0.126 (Local lab (IS); 05/2016 - 0.195 (local); 6/2016 - 0.07 (MDA); 7/2016 - 0.03 (local) 9/13/2016 - 0.16 (MDA); 9/26/2016 - 0.31 (MDA); 11/2016 - 0.012 (local); 01/2017 - 0.24 (MDA); 04/2017 - 0.09 (MDA); Cytogenetics show der(1:7)(q10;p10)7 chromosome mutation. Repeat of Sep 2015. PCR - 6/2017- 0.035 (local); 10/2017- 0.02 (MDA)
Posted 02 December 2017 - 11:41 PM
A friend of mine is an expert in DNA in genealogy. I've sent her your question, will let you know if she replies.
DX 09-2011 PCR 8.08 not IS WBC 17 , Began Tasigna 600mg
in 2012 Tasigna 450mg/day ,in 2013-2017 Tasigna 300mg/day
09-11/ 8.08 not IS
03-12/ 0.054 not IS
06-12/ 0.035 not IS
09-12/ PCRU, 01-13/ PCRU
4-13/ 0.042 IS
7-13/ 0.014 IS
11-13/ PCRU, 04-14/ PCRU
8-14/ 0.006 IS
PCRU: 12-14/ 05-15/ 10-15/ 02-16/
09-16/ 02-17/ 09-17/
10-17 tapered off
11-3-17 Stopped Tasigna
1-15-18 still PCRU
Posted 04 December 2017 - 11:18 AM
Thanks. I'd like to hear from an expert instead of a customer service representative.
Posted 05 December 2017 - 10:41 AM
I joined 23&Me during their Blood cancer trial. I haven't seen anything there that suggests having CML had an impact on what they deliver.
Posted 05 December 2017 - 10:55 AM
Posted 05 December 2017 - 12:09 PM
My blood counts were well back to normal when I joined, so I can't speak to that.
Posted 06 December 2017 - 10:57 AM
This type of test looks at broken down DNA from saliva white blood cells. I do not believe the ancestry testing could see full chromosomes since the sample collection process does not preserve full cell chromosome structure, only the pieces of DNA which has been broken down, and CML is not discoverable in the DNA except by looking at full chromosomes. From looking at the pieces of DNA the test results paint a chromosome map, but chromosome 22 is partially vacant in their testing process where the CML translocation would be found if it were even discoverable (which I highly doubt). Also, saliva has almost no higher level blood cells (i.e., no stem cells). Because of that, there would not be a marker of CML for anyone who has responded to TKI drugs past CCyR (a zero FISH).
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