https://www.news-med...tudy-shows.aspx
Existing-drugs-may-be-able-to-improve-therapy-for-chronic-myeloid-leukemia-mice-study-shows.
Started by
gerry
, Oct 13 2017 07:02 PM
6 replies to this topic
#2
Red Cross Kirk
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Posted 13 October 2017 - 10:09 PM
So, have any of us used a TKI and prostaglandin or misoprostol at the same time? If so, did you achieve PCRU while taking the combination?
Kirk
9/25/2012 p210 transcript 118.7% IS @ Dx, begin Gleevec 400mg/day
12/2012 3.59% & bone marrow biopsy - no residual myeloproliferative features but detected 1/20 metaphases containing the Philadelphia chromosome
2013 0.914%, 0.434%, 0.412%
10/2013 0.360% & bone marrow biopsy - normal male karyotype with no evidence of a clonal cytogenetic abnormaltiy
2014 0.174%, 0.088%, 0.064%
2015 0.049%, decrease to Gleevec 200mg/day, 0.035%, 0.061%, 0.028%
2016 0.041%, 0.039%, 0.025%
2017 0.029%, 0.039%, switched to generic imatinib 200mg/day, 0.070%, 0.088%
2018 0.233%
#3
Sandrea
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Posted 14 October 2017 - 09:28 AM
I don't like this phrase "mice treated with only imatinib, all of which died within 60 days".
Why did they all died? Is it some special mice?
Diagnosed 1 April 2015. WBC 86000; b2a2 (p210) transcript
on Hydrea for 2 months, then generic Gleevec 400mg (06/06/15)
CCyR in April 2016
12/22/2016 PCR: 0.49% (IS) 18 Month
03/29/2017 PCR: 0.68% (not IS) 21 Month
06/06/2017 PCR: 1.62% (not IS) 24 Month
06/20/2017 increased dose of imatinib to 600mg
10/30/2017 PCR: 0.15% (not IS) 28 Month
#4
Red Cross Kirk
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Posted 14 October 2017 - 10:48 AM
I don't like this phrase "mice treated with only imatinib, all of which died within 60 days".
Why did they all died? Is it some special mice?
I've read some of the report, but don't pretend to understand much of it. My guess is that they let the CML progress in the mice before they began treatment, or that they used an especially virulent variant of CML for the research.
Kirk
9/25/2012 p210 transcript 118.7% IS @ Dx, begin Gleevec 400mg/day
12/2012 3.59% & bone marrow biopsy - no residual myeloproliferative features but detected 1/20 metaphases containing the Philadelphia chromosome
2013 0.914%, 0.434%, 0.412%
10/2013 0.360% & bone marrow biopsy - normal male karyotype with no evidence of a clonal cytogenetic abnormaltiy
2014 0.174%, 0.088%, 0.064%
2015 0.049%, decrease to Gleevec 200mg/day, 0.035%, 0.061%, 0.028%
2016 0.041%, 0.039%, 0.025%
2017 0.029%, 0.039%, switched to generic imatinib 200mg/day, 0.070%, 0.088%
2018 0.233%
#5
Gail's
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Posted 14 October 2017 - 11:36 AM
Not sure what the life span of a lab mouse is but the ones in the wild live 5 months to 2 years according to google.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#6
kat73
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Posted 14 October 2017 - 05:35 PM
Sooooo, are they going to call this Viagra Plus?
Seriously, though, I hope this pans out. Although, being female, it feels kinda icky . . . I'll get over it!
Dx July 2009 on routine physical. WBC 94. Started Gleevec 400 mg Sept 2009. MMR at 2yrs. Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved. Kidney issues developed because of Gleevec. Switched to Sprycel 70 mg in Aug 2011. Above side effects disappeared or improved. Have been MR3.5 - 4.5 ever since. Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017. After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS. Pleural effusion returned within a couple of months, same as before (moderate, left side only). Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved. At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.
#7
ROMO
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Posted 14 October 2017 - 05:41 PM
If it works on mice then it will only work on a part of me.
The mouse part.
Romo
DX August 2016. WBC ~160K
PH+ Cells 36%
No Spleen enlargement
No Symptoms. Other counts ~Normal
BCR-ABL p210 (Detected)
BCR-ABL p190 (Not Detected)
Sprycel 100mg.
PCR 02/01/2017 0.146 IS
PCR 08/07/2017 0.022 IS
Next PCR: 12/XX/2017
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