I have been on Sprycel since I was diagnosed in May 2016 - started with 100 mg and dropped to 80 mg 3 months ago. I am in MMR but not deep - hover around 0.02/0.05 for the last 6 months.
My side effects are fatigue, less focus (likely due to fatigue), and varying muscle aches/pains (depends on the day). These are manageable but not ideal given I will be on it for at least another 2+ years and I work full time with 2 kids (7, 11). I try to exercise at least 2x a week and with my busy life that is as good as it is going to get minus a couple of extra short walks during the week if I am able. I try and work from home once a week to help manage the fatigue which keeps me sane since with kids my weekends are as busy as the workweek. And I try to take regular baths, stretch, massage, etc.
My doc has mentioned that if I am uncomfortable she would support me switching to bosutinib/bosulif. I am hesitant - I feel like it might be a devil you know kind of situation. Given that my side effects aren't terrible and I expect every TKI has them...I'm not sure it is worth switching particularly if I will have to spend a few weeks adjusting to a new medication (ie, not be able to function/work/take care of my kids). I'm also not seeing much on the forum about bosulif side effects that make me feel great about switching (ie, still fatigue, really bad GI side effects, etc).
Anyone have any thoughts to share who might be in a similar situation?