4 replies to this topic

[survenant]

"In 2002, Professor Holyoake was the first to demonstrate that CML stem cells are completely insensitive to killing by first generation kinase inhibitor, imatinib. These findings published in Blood highlighted that kinase inhibitors alone would be unlikely to cure CML."

.....

A recent study, led by Prof Holyoake analysed both CML and normal blood stem cells and found two proteins that were key to the survival of CML stem cells. The group then developed a drug combination to simultaneously target these critical proteins and kill the CML stem cells, while largely sparing normal cells. This research, published in Nature, although at an early stage, is a fantastic example of precision medicine in action."

 

Extract of "Prof Tessa Holyoake recognised for ground-breaking research into CML"

http://www.glasgowci...search-into-cml

 

 

Learn more about  Professor Tessa L Holyoake   ------- See the videos

[r06ue1]

That really sucks, she was leading the efforts in targeting CML stem cells and the possible cure for CML.  

[r06ue1]

She was just recently awarded a medal by the Queen for her breakthrough research into eradicating CML stem cells.  

 

http://www.gla.ac.uk..._535050_en.html

 

Huge loss to the CML community.  

[kat73]

Tragic.  Really young!  Is the Glasgow team anywhere near clinical trial time?

[r06ue1]

The last link I provided talks about the team being awarded $3 million from a European agency for the first trial so I would assume it will begin soon.