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Cranberry extract


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#1 Karinne

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Posted 31 August 2017 - 03:18 PM

Hi everyone,

as you can see in my signature, I had a scary moment, last year, when my pcr went from 0.00046 to 0.006 in 6 months and 0.0024, another 3 months later.

Even if I was not passed "safe heaven" (0.1%), the bad trend was dangerous. I checked every thing that have changed in the past 6 months and I realized that I was taking Cranberry extract (to prevent UTIs) for 7 months. I stopped the cranberry immediately and my pcr went back down in the next months, to less than MR4.5 in 8 months.

Afterward, I found articles that mentioned cranberry and Warfarin and also cranberry extract and Tacrolimus interactions.

Two messages to take home:

1) it is better to avoid cranberry extract with TKIs, but I think that cranberries are okay.

2) think twice before adding any diet supplements even if they look as innocuous than cranberry.

Thank you.


Dx : 12/13/13 Sprycel 100mg Platelets around 100
December 2014 pcr = 0.0032%IS
December 2015 pcr = 0.00046%IS
October 2016 pcr = 0.024%IS (increase due to Cranberry Extract)
July 2017 pcr < 0.0032%IS
October 2017 pcr < 0.0032%IS
January 2018 PCRU !!!!!!!!!

#2 gerry

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Posted 31 August 2017 - 05:21 PM

I do take supplements took them prior to taking Gleevec, while on Gleevec and continue to take them now I have been treatment free for almost 4 years.
I agree that you need to do your research on what supplements you take. :-)

Had a look at info on cranberry juice - one of the "good" properties is
. Chelation - Proanthocyanidins have a strong iron chelating capability, meaning that cranberry's antioxidants binds to toxic drugs and metals making it easier for the liver to remove.

But that isn't necessarily a good thing to have your TKI passed out of your body too quickly.

#3 ROMO

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Posted 31 August 2017 - 06:05 PM

Karinne,
 
As one new member to another...
 
I hope cranberries are not on the 'Do not do list'.
I love those little buggers. Every year we go to the cranberry
boggs on the Washington coast and enjoy the festivals.
Have you ever had cranberry and chocolate?
You will love your mouth so much you will never cuss again.
 
Ocean Spray the cranberry people own alot of that place.
You drive in squared elevated roads and see houses perched up in
the middle of cranberry boggs. People live in those hoses and own the
bogg. The boggs floods when the owner opens the flood gate. They
harvest the cranberries by banging on the water and the cranberries float
to the surface and are scooped up. A kind of farm sounded by pools of
cranberries.
 
But I think this has to do with how the liver produces enzymes
in highly acidic environments. That Sprycel needs the liver to absorb
it's molecules it needs the liver to be unencumbered  with other
distractions.  Our liver is our friend and partner.
I've named my liver, Liver McLoveit. He's doing such a good job.
 
By the way your numbers look really good.
Hoping you reach PCRU next test.
 
Romo

DX August 2016. WBC ~160K
PH+ Cells 36%
No Spleen enlargement
No Symptoms. Other counts ~Normal
BCR-ABL p210 (Detected)
BCR-ABL p190 (Not Detected)
 
Sprycel 100mg.
PCR   02/01/2017    0.146 IS
PCR   08/07/2017    0.022 IS
Next PCR:           12/XX/2017
 

#4 Lucas

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Posted 10 September 2017 - 01:07 PM

Funny thing is that cranberries are a CYP3A4 inhibitor, so you should had more drug in your system, and not less.



#5 gerry

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Posted 10 September 2017 - 03:35 PM

They think cranberry juice may interact with warfarin as it affects CYP450 enzyme http://www.pharmacis...ients-need-know

#6 Karinne

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Posted 11 September 2017 - 10:26 AM

I found this article about cranberry extract and Tacrolimus. Tacrolimus like TKIs is a substrate of CYP3A4. And in this story, cranberry extract decreased the concentration of the drug.
http://assets.cureus...499-1ms40ts.pdf

Lucas, I think that the story with CYP3A4 inhibitor is complicated: you have intestinal CYP and liver CYP. The first one helps the absorption of drugs and the second helps the degradation. They have opposite effects. Even for grapefruit they say that it could increase or decrease the drug concentration.
Dx : 12/13/13 Sprycel 100mg Platelets around 100
December 2014 pcr = 0.0032%IS
December 2015 pcr = 0.00046%IS
October 2016 pcr = 0.024%IS (increase due to Cranberry Extract)
July 2017 pcr < 0.0032%IS
October 2017 pcr < 0.0032%IS
January 2018 PCRU !!!!!!!!!




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