Posted 30 August 2017 - 03:38 AM
Am new to this forum
My husband is a cml patient from October 2011
He takes 400mg generic imatinib tablet.
His bcr-abl was 0% for the past 3 years.
Unfortunately this year it has gone up to 10.88%
Met the hematologist with his report. He has asked us to repeat the test . Worried kindly advice
My husband is 64 yrs old & we are from india.
Taking generic drug since we can't afford to buy the original
Posted 30 August 2017 - 07:03 AM
I am guessing that you mean PCR test results, going from 0% (typically this is indicated as 0.0% or 0.000%, depends on the lab) to over 10% might indicate a mutation. Has he had a bone marrow biopsy since his numbers began to rise? Has he been taking his medication every day? If there is no mutation and he has been taking his medication every day he would need to switch drugs. Next step is to get the BMB and mutation test done.
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
Posted 30 August 2017 - 07:19 AM
Posted 30 August 2017 - 07:21 AM
Posted 30 August 2017 - 09:02 AM
Repeating the PCR is the right approach. The PCR test can have false positive results due to lab errors. A sudden loss of response after 6 years with several years at 0 PCR is very rare, but it is not impossible.
Is he taking any other medications?
Posted 30 August 2017 - 09:21 AM
Posted 15 September 2017 - 09:37 AM
Posted 15 September 2017 - 10:43 AM
So glad to hear this. We all know the pain that test caused. It would have destroyed me.
10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users