7 replies to this topic

[Karinne]

Hello everyone, this is my first post.
I was diagnosed at the end of 2013 and I am on Sprycel 100 mg. My pcr is low, detectable but below the quantitative range (between MR4.5 and MR5). My question is about Niacin, I would like to lower my cholesterol by taking Niacin. Do you know if it is safe with Sprycel? Thanks in advance.

[Trey]

Niacin is fine with Sprycel, it is an essential vitamin.

 

But 1000mg is way overboard.  16mg is the RDA.  I would not take that much.  I believe a little is good, but more is not necessarily better.

 

My Dad had success with red yeast rice extract.  He was not a vitamin junkie but that worked well for him. 

"One of the most important ingredients in RYRE is monacolin K. It's also known as lovastatin, the active ingredient in the prescription drug Mevacor."

http://www.webmd.com...ed-yeast-rice#1

[gerry]

I haven't tried RYRE yet, nice to know it might work. The amount of Niacin you need to take comes with a number of side effects, so not something I want to try.

[cmljax]

I take 1,000 mg per day of Niacinamide (a derivative form of Niacin that has fewer side effects than Niacin, particularly flushing) as directed by my dermatologist because there is clinical evidence that this decreases the incidence of squamous cell skin cancers.  I had 9 confirmed SCSC's when I first started taking 600 mg Tasigna last fall.  I am now on 300 mg and have had no new SCSC's since March.

 

That being said, Niacinamide is not appropriate for cholesterol reduction.  Niacin in high doses like you suggest can have bad side effects and I would not advise doing this without consulting with my doctor.  There is a prescription strength Niacin for high cholesterol that you could possibly take, but there are also statins.  I am on 20 mg simvastatin and there is no adverse interaction with Tasigna.

 

Good luck whatever you decide to do

[Karinne]

Thank you all for your responses. I will not try Niacin (1g) to lower my cholesterol.

I just wanted to avoid statins that have side effects too. In particular, some statins will compete with the same metabolic pathway than TKIs, namely CYP3A4. I am happy that Cmljax does not have side effect with Simvastatin and Tasigna, although they both use the (in)famous CYP3A4. This might increase the side effects from statins. Other statins, like Fluvastatin or Rosuvastatin use CYP2A9 and should be better suited with TKIs? Of course, this is the theory and in practice, apparently it is fine for some. That is why this forum is so important for me.

Until next time, have a wonderful day.

[gerry]

I was on Gleevec, but actually found I could go off the statin and bp med, one of the best side effects of the Gleevec. When I stopped the TKI, my cholesterol and bp started to rise again. I returned to the statin and started to have muscle issues with it, I can't even take it at lose dose now in a combination pack.

[gerry]

I did wonder if the Gleevec made the statin hang around longer in the liver or whether the Gleevec impacted my liver enough to slow down the cholesterol production.

[ROMO]

Nicine is an organic vassal dilator. that it helps with cholesterol has to do

with it makes your vanes dilate bigger and the plugged vanes have

increased blood flow. It's like driving slower because your breaks are

faulty. Skin flushing is because your vanes are pumping faster blood.

 

Blood cholesterol is pre-programmed in your metabolism. Some eat fat

and are skinny, some people eat skinny and are fat. We are our own

unique Temple.

 

Romo