Javascript Disabled Detected

You currently have javascript disabled. Several functions may not work. Please re-enable javascript to access full functionality.

Blood Transfusion

Started by Goldfinger , Aug 18 2017 11:35 AM

Please log in to reply

9 replies to this topic

#1 Goldfinger

Member

Members
19 posts

Posted 18 August 2017 - 11:35 AM

This is a hypothetical question only. You have a member of your family who needs a blood transfusion immediately. You are the only available donor and have cml. Would they reject you on that basis only? Or would they allow you to donate? Any opinions one way or another?

Back to top

#2 Gcasa

Advanced Member

Members
1,099 posts

Posted 18 August 2017 - 01:05 PM

Most probably reject.
Blood banks carry units of blood for emergencies.

Back to top

#3 kat73

Advanced Member

Members
884 posts

LocationWashington, DC area

Posted 18 August 2017 - 03:49 PM

Oh Holy Cow! I sure wouldn't want my blood! Please tell me we'd all be rejected!!!

Dx July 2009 on routine physical. WBC 94. Started Gleevec 400 mg Sept 2009. MMR at 2yrs. Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved. Kidney issues developed because of Gleevec. Switched to Sprycel 70 mg in Aug 2011. Above side effects disappeared or improved. Have been MR3.5 - 4.5 ever since. Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017. After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS. Pleural effusion returned within a couple of months, same as before (moderate, left side only). Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved. At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.

Back to top

#4 mikefromillinois

Advanced Member

Members
93 posts

Posted 18 August 2017 - 05:47 PM

From the Red Cross:

Eligibility depends on the type of cancer and treatment history. If you had leukemia or lymphoma, including Hodgkin's Disease and other cancers of the blood, you are not eligible to donate. Other types of cancer are acceptable if the cancer has been treated successfully and it has been more than 12 months since treatment was completed and there has been no cancer recurrence in this time. Lower risk in-situ cancers including squamous or basal cell cancers of the skin that have been completely removed do not require a 12 month waiting period.

Back to top

#5 scuba

Advanced Member

Members
1,044 posts

LocationHouston, Texas

Posted 19 August 2017 - 08:52 AM

from the national CML society:

"...leukemic cells of a random donor would be seen as foreign, they would be immediately destroyed by the recipient. There is no evidence that leukemia has ever been acquired from a blood transfusion."

However,

https://www.scienced...70720095342.htm

"Reports of transmission of cancer cells from needles or surgical instruments demonstrate that tumours cells have the capability to be transplanted to, and develop in, healthy recipients. And there is some data to show that transfused patients are at increased risk of cancers, particularly non-Hodgkin lymphoma."

Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale)

March 2017 PCR: 0.01% (M.D. Anderson scale)

June 2017 PCR: "undetected"

September 2017 PCR: "undetected"

Back to top

#6 Goldfinger

Member

Members
19 posts

Posted 19 August 2017 - 11:08 AM

Before I was diagnosed with CML, I was a regular donor at the Red Cross. Seems like they could at least use the plasma since it doesn't contain any red blood cells and therefore no possible contamination from CML.

Back to top

#7 Trey

Advanced Member

PS Beta Group
1,705 posts

LocationSan Antonio, Texas

Posted 20 August 2017 - 08:54 AM

Seems like they could at least use the plasma since it doesn't contain any red blood cells and therefore no possible contamination from CML.

There is no way to completely cleanse the plasma of all cells since blood separation is only partially successful. Also as a clarification, at the working blood cell level CML is only in the white blood cells. Red blood cells have no nucleus so are "neuters". And platelets are not cells, but cell fragments.

However, all blood cells are formed by progenitor cells which have a nucleus, and with CML all higher order blood progenitor and stem cells can be leukemic including those which make any of the three types of blood cells. These higher order blood cells will be in any transfusion.

Regarding transmission of CML it would be very unlikely but not impossible. Among siblings it would be more likely than outside of the family.