Posted 18 August 2017 - 11:35 AM
Posted 18 August 2017 - 01:05 PM
Blood banks carry units of blood for emergencies.
Posted 18 August 2017 - 03:49 PM
Oh Holy Cow! I sure wouldn't want my blood! Please tell me we'd all be rejected!!!
Dx July 2009 on routine physical. WBC 94. Started Gleevec 400 mg Sept 2009. MMR at 2yrs. Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved. Kidney issues developed because of Gleevec. Switched to Sprycel 70 mg in Aug 2011. Above side effects disappeared or improved. Have been MR3.5 - 4.5 ever since. Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017. After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS. Pleural effusion returned within a couple of months, same as before (moderate, left side only). Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved. At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.
Posted 18 August 2017 - 05:47 PM
From the Red Cross:
Eligibility depends on the type of cancer and treatment history. If you had leukemia or lymphoma, including Hodgkin's Disease and other cancers of the blood, you are not eligible to donate. Other types of cancer are acceptable if the cancer has been treated successfully and it has been more than 12 months since treatment was completed and there has been no cancer recurrence in this time. Lower risk in-situ cancers including squamous or basal cell cancers of the skin that have been completely removed do not require a 12 month waiting period.
Posted 19 August 2017 - 08:52 AM
from the national CML society:
"...leukemic cells of a random donor would be seen as foreign, they would be immediately destroyed by the recipient. There is no evidence that leukemia has ever been acquired from a blood transfusion."
"Reports of transmission of cancer cells from needles or surgical instruments demonstrate that tumours cells have the capability to be transplanted to, and develop in, healthy recipients. And there is some data to show that transfused patients are at increased risk of cancers, particularly non-Hodgkin lymphoma."
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
Posted 19 August 2017 - 11:08 AM
Posted 20 August 2017 - 08:54 AM
Seems like they could at least use the plasma since it doesn't contain any red blood cells and therefore no possible contamination from CML.
There is no way to completely cleanse the plasma of all cells since blood separation is only partially successful. Also as a clarification, at the working blood cell level CML is only in the white blood cells. Red blood cells have no nucleus so are "neuters". And platelets are not cells, but cell fragments.
However, all blood cells are formed by progenitor cells which have a nucleus, and with CML all higher order blood progenitor and stem cells can be leukemic including those which make any of the three types of blood cells. These higher order blood cells will be in any transfusion.
Regarding transmission of CML it would be very unlikely but not impossible. Among siblings it would be more likely than outside of the family.
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