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Does the cost of Imatinib change?


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#21 Buzzm1

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Posted 22 July 2017 - 09:44 PM

My cost for Bosulif went up about 5% mid-year

Haven't checked the prices on any of the TKIs for quite a while.  What is the quoted price on your Bosulif?  Thanks in advance.

 

Same for Tasigna - up 5% at mid-year

What is the quoted price on your Tasigna?  Thanks in advance.


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt


#22 Mosey

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Posted 23 July 2017 - 03:37 AM

Hi Everyone,

 

 I have had CML since November 2002 and have been on 600 mg Gleevec since my DX.

 

Are you sure you're not looking at the Brand name Gleevec? Brand name Gleevec is $11,053.70 for 400mg & $5,829.09 for the 400mg tablets. That is the pharmacy price from my mail order. Based on the Medicare's Catastrophic Stage, the total for 600mg would be $844.14 a month for the Brand Name Gleevec based on straight Medicare, no Advantage plan.

 

When I checked into getting the medication at my local Walgreen's or Walmart, I was told that this is a specialty drug and I had to order it through a certain pharmacy and could not go to my local one. Those are the rules of my Part D plan.

 

Hope this information was useful.

 

Mosey :)



#23 chriskuo

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Posted 24 July 2017 - 12:32 AM

The price quoted for Bosulif was about $9,050 earlier this year to about $9,320/month



#24 Buzzm1

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Posted 24 July 2017 - 12:18 PM

The price quoted for Bosulif was about $9,050 earlier this year to about $9,320/month

If I recall correctly you take 300mg of Bosulif, so that would be $103.56 per 100mg.


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt


#25 Dom

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Posted 26 July 2017 - 06:43 PM

Mosey, no I'm looking at Imatinib.  The medicare site even notes that this is "already generic".  The prices you quote are very near the priices that are coming up at the medicare site.  

 

In any case, I just this morning purchased a new month of imatinib, 400s and 100s, and the total price came to $148.85 (in catastrophic phase).  So I"m not sure why the medicare site is giving the wrong information.  


Diagnosed in February 2014. Started Imatinib 400 in April.
2014:     3.18     0.91
2015:     0.22     0.16     0.04     0.55
2016:     0.71     0.66

(Started Imatinib 600 in April 2016)
2016:     0.42     0.13     0.45
2017:     0.17     0.06     0.10     0.06     0.34


#26 carrie

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Posted 29 July 2017 - 10:52 AM

DOM I sent you a private message.


Diagnosed   2007

On Gleevec for 10 years

Results from 2007-2012 not shown below

International Scale from 2012 until now

Never went to 0

0.166

0.038

1.155

0.789

0.104

0.099

0.701

1.986

1.063

1.799

2.817

1.832

3.449

1.050

1.438

3.376

3.370

3.370

2.580

8.990

4.250

6.176

14.109   Changing to Tasigna 7/7/17

 

7/28/17  800 mgs Tasigna

10/5/17  600 mgs Tasigna (Lots of bad side effects)

10/16/2017    PCR down to 0.141  

1/15/18          PCR down to  0.066   Dose reduction again. Now 400 mgs daily.


#27 Dom

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Posted 29 July 2017 - 11:03 AM

Carrie, I just sent a reply.

Diagnosed in February 2014. Started Imatinib 400 in April.
2014:     3.18     0.91
2015:     0.22     0.16     0.04     0.55
2016:     0.71     0.66

(Started Imatinib 600 in April 2016)
2016:     0.42     0.13     0.45
2017:     0.17     0.06     0.10     0.06     0.34


#28 hannibellemo

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Posted 30 July 2017 - 01:08 PM

Yes Shweflen, I'm jealous. It happened pretty fast for you too.

Express-scripts still sends me mail asking me to buy my meds through mail order, or at Walgreens, even though the prices are much higher for them and me both.

Dom,

 

I keep getting the same stuff from Humana even though the Medicare site showed that mail order would be more expensive and while Humana has a special agreement with WalMart it doesn't save me enough money to make the drive across town worth it! I get Sprycel 50 mg at my HyVee pharmacy that is 5 minutes away. BTW, after reaching catastrophic coverage my cost for that is @$392.

 

You've just reminded me that I have to review all this Medicare stuff in October.  :(


Pat

 

"You can't change the direction of the wind but you can adjust your sails."

DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>


#29 scuba

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Posted 31 July 2017 - 10:39 AM

It does seem generic gleevec (imatinib) is much cheaper than brand name gleevec:

 

https://www.canadadr...s/gleevec/400mg


Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

 

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

 

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"


#30 chriskuo

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Posted 01 August 2017 - 02:21 AM

I don't think you can use Canadian drug prices as a accurate proxy for US drug prices, but it does make sense that the price of generic imatinib would drop significantly as multiple players enter the market and battle for market share.

 

Since most Americans get their drugs through some chain of insurance company / pharmacy, the is virtually no visibility to what the drug company is receiving for the drugs.  Most reports indicate that for patented specialty drugs, the discounts are in the 30-40% ranges.

You would expect the discount for specialty generics to be lower, but not as low as for standard generics which are pretty competitive and relatively low margin to start with.






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