http://www.haematolo...102/7/1131?etoc
Treatment Free Remission
Started by
Sneezy12
, Jun 27 2017 08:14 AM
6 replies to this topic
#2
scuba
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Posted 27 June 2017 - 08:58 AM
from the article Sneezy linked above (emphasis mine):
"Only 50% of deaths are due to the progression of leukemia, while 50% occur in remission and are due to other causes which occasionally include treatment-related toxicity and related complications"
"In summary, once a deep MR is achieved, and provided that careful molecular monitoring is assured, no patient will die of leukemia because of treatment discontinuation, and 50% will enjoy a treatment-free life. Therefore, we suggest that both the possibilities and the problems of treatment discontinuation should be discussed not only with all the patients who fit the current, provisional eligibility criteria for discontinuation, but also with newly diagnosed patients."
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
#3
Trey
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Posted 27 June 2017 - 07:47 PM
A very good quote from the article:
"For the time being we must acknowledge that any recommendation concerning the policy of treatment regarding TFR is not yet evidence-based."
#4
scuba
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Posted 28 June 2017 - 02:12 AM
A very good quote from the article:
"For the time being we must acknowledge that any recommendation concerning the policy of treatment regarding TFR is not yet evidence-based."
The very next sentence after your quoted one:
"In all likelihood, the best policy does not exist, and different policies may be successful in different situations."
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
#5
Trey
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Posted 28 June 2017 - 08:32 AM
In other words, no one knows anything about why or when cessation will work.
#6
scuba
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Posted 28 June 2017 - 09:17 AM
In other words, no one knows anything about why or when cessation will work.
Except that for about 50% of PCRU patients, cessation works. In addition, risk of progression following a failed cessation attempt and TKI re-start is for all practical purposes - zero.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
#7
gerry
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Posted 28 June 2017 - 05:00 PM
The trouble is they may think they have some of the criteria for successfully stopping, but it is still hit and miss.
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