Advanced Member
Posted 19 June 2017 - 10:13 AM
Hi fellow CMLers, I just got results back from a PCR that was great news (<.01) (after 3.5 years of Sprycel 100mg) and had a quick question about the report. It said the assay found BCR/ABL transcripts in 1 out of 2 replicates - does that mean they split the sample and run two tests simultaneously?
Many thanks in advance.
DX 6/2013
Sprycel 100mg
CCR 3/2015
MMR 2/2016
<.01 IS 10/16 hopkins didn't report actual percentage
.007 IS 6/2017
<.01 12/2017 again no actual percentage but didn't see the report myself yet
Advanced Member
Posted 19 June 2017 - 11:06 AM
Aha! Finally one that I can answer for sure! I had the same question. My onc explained that there are indeed two samples made up for testing and what happens is, they test one and if it is positive, they measure it and don't test the second one - they throw it away. But if they find nothing in the first sample, they test the second one, and if it's positive, that is the number you will receive on your report, indicating that they found the transcripts in one out of two samples. So, presumably, if you get "undetectable" on your report, that means they tried the first one and found nothing, went on to the second one and also found nothing.
Dx July 2009 on routine physical. WBC 94. Started Gleevec 400 mg Sept 2009. MMR at 2yrs. Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved. Kidney issues developed because of Gleevec. Switched to Sprycel 70 mg in Aug 2011. Above side effects disappeared or improved. Have been MR3.5 - 4.5 ever since. Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017. After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS. Pleural effusion returned within a couple of months, same as before (moderate, left side only). Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved. At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.
Advanced Member
Posted 19 June 2017 - 01:04 PM
Kat thanks!
DX 6/2013
Sprycel 100mg
CCR 3/2015
MMR 2/2016
<.01 IS 10/16 hopkins didn't report actual percentage
.007 IS 6/2017
<.01 12/2017 again no actual percentage but didn't see the report myself yet
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