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Low dosage maintenance Sprycel successful so far


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#21 scuba

scuba

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Posted 26 July 2017 - 05:31 PM

Great news that you are still undetectable mscl especially after your experience with the severe rash.

 

Just got my latest BCR ABL results this morning.

 

Although I realise there is a lot of variability in sensitivity at this level I'm a bit disappointed. I was getting over-ambitious in my thinking... hoping to reach PCRU some time soon and then be able to reduce dose gradually again. But now I am just hoping to be able to stay on 50mg per day as more than that has a big impact on me in terms of side effects.

 

I see my doctor tonight and I am sure he will urge me to increase my dose.

 

 

M.A.

From your signature line:

 

April 2017 0.0079 (MR4, Woo Hoo!!!)

July 2017 0.014 (Hmm...)

 

Another way to read your PCR results:

 

April 2017 0.01 (MR4)

July 2017  0.01 (MR4)

 

No change. Third decimal place in PCR measurements is meaningless.

 

You would be wise in staying the course on 50 mg Sprycel.


Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

 

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

 

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"


#22 M.A.

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Posted 26 July 2017 - 07:10 PM

Thanks scuba. I appreciate your way of interpreting my PCR results!


CML diagnosed April 2016

Type One Diabetes diagnosed April 1980 (age 12)

 

BCR-ABL (IS)

46.77  April 2016

3.568  July 2016  

0.076  Oct 2016

0.016  Feb 2017

0.0079  April 2017

0.014  July 2017

0.019  Sept 2017

0.011  Nov 2017

0.019  Jan 2018

 

Sprycel

100mg April 29 - September 22

75mg  September 23 - October 28

50mg October 29 2016 to present





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