Another new way of targeting CML (and AML, lung and breast cancers) and curing it:
Scientists Find Possible Achilles Heel of Treatment-resistant Cancers
http://www.bioscienc...sistant-cancers
Scientists Find Possible Achilles Heel of Treatment-resistant Cancers
Started by
r06ue1
, Mar 28 2017 10:10 AM
7 replies to this topic
#1
r06ue1
-
- Members
-
- 426 posts
Advanced Member
- LocationEarth, Solar System, Milky Way, Local Group, Virgo Supercluster, Laniakea
Posted 28 March 2017 - 10:10 AM
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
#2
scuba
-
- Members
-
- 1,044 posts
Advanced Member
- LocationHouston, Texas
Posted 28 March 2017 - 12:06 PM
This is very exciting ... Here is additional info:
https://www.ncbi.nlm...pubmed/28319094
I have asked to be put in a trial involving the combination therapy to test residual disease removal.
(patent: https://www.google.c.../US20140031356)
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
#3
Frogiegirl
-
- Members
-
- 259 posts
Advanced Member
Posted 28 March 2017 - 07:04 PM
How would we get in the trial?
Diagnosed Oct 2013 Started 600mg of Tasigna on Nov 4th. Lowered dose a few months later to 300mg due to side affects stayed here declining PCR until March 2015 small jump from 0.0072 to 0.0083 scarred my doc into full dose of Tasigna again 600mg(been miserable since) but reached PCRU 06/15/2015(next test) and have been there ever since. Hoping to have another little one. I have the support of my doc to go off anytime, just scared to jump. might go two years PCRU but he said it wont make much of a difference. I just figured I could possibly go into a trial while preggers if I got the two years behind me.
Nov 8th 2017 went off Tasigna
Dec 1st PCRU off TKI
Jan 5th PCR Detected .0625
Feb 1st PCR Detected .7815
Added 8-6 grams Curcumin daily in Feb
March 3rd PCR Detected 3.2646 YIKES!
stopped trying for baby after February reading. will start new TKI march 16th 2017 (Sprycel)
FYI I'm not done trying for my last little one.
#4
scuba
-
- Members
-
- 1,044 posts
Advanced Member
- LocationHouston, Texas
Posted 28 March 2017 - 07:53 PM
How would we get in the trial?
I just asked my Oncologist that should a trial become available for a combination treatment of Sprycel + Abl001, to add me to the list.
I have little hope that this will happen anytime soon. He told me in the past that trials of this type are for patients who have not responded and are in more serious need. Patients like us who do respond to treatment are low on the list.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
#5
TeddyB
-
- Members
-
- 203 posts
Advanced Member
Posted 30 March 2017 - 03:17 AM
This is very exciting ... Here is additional info:
https://www.ncbi.nlm...pubmed/28319094
I have asked to be put in a trial involving the combination therapy to test residual disease removal.
Thanks for the links, i cleaned up the patent link so it works directly:
https://www.google.c...s/US20140031356
#6
kat73
-
- Members
-
- 884 posts
Advanced Member
- LocationWashington, DC area
Posted 03 April 2017 - 05:50 PM
This sounds terrific, but I'm curious about a couple things: Why didn't the new therapy alone kill leukemic cells, in the manner imatinib does? In other words, how/why does the combo work? And, second, how did they know the CML was cured? I was under the impression that no one can even see one of our stem cells, let alone know when all the bad ones are killed.
Dx July 2009 on routine physical. WBC 94. Started Gleevec 400 mg Sept 2009. MMR at 2yrs. Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved. Kidney issues developed because of Gleevec. Switched to Sprycel 70 mg in Aug 2011. Above side effects disappeared or improved. Have been MR3.5 - 4.5 ever since. Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017. After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS. Pleural effusion returned within a couple of months, same as before (moderate, left side only). Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved. At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.
#7
r06ue1
-
- Members
-
- 426 posts
Advanced Member
- LocationEarth, Solar System, Milky Way, Local Group, Virgo Supercluster, Laniakea
Posted 04 April 2017 - 06:42 AM
Hi Kat,
I think two articles I posted the same day sort of got intertwined here, the article in this post refers to two new targets (c-Fos and Dusp1 proteins) for drugs which specifically target LSC's and the other article was on ABL001 which Novartis has found when combined with other medicines we use today prevents (not sure about cure though they use that word) CML from coming back in mice (not enough evidence yet in Human's).
Researchers have been working with LSC's for quite some time, some articles I had read date to 2007 and perhaps even earlier.
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
#8
kat73
-
- Members
-
- 884 posts
Advanced Member
- LocationWashington, DC area
Posted 04 April 2017 - 08:43 AM
Yes, I was catching up here after being away, and reading from the bottom up. I caught the other articles after I posted. I think I still missed the memo somewhere back in time that LSC's can be identified and watched. I thought the whole problem was they lurked silently in their bone marrow niche, hiding from view and any verifiably successful attack. Glad I'm wrong?
Dx July 2009 on routine physical. WBC 94. Started Gleevec 400 mg Sept 2009. MMR at 2yrs. Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved. Kidney issues developed because of Gleevec. Switched to Sprycel 70 mg in Aug 2011. Above side effects disappeared or improved. Have been MR3.5 - 4.5 ever since. Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017. After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS. Pleural effusion returned within a couple of months, same as before (moderate, left side only). Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved. At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users
