I'm not alarmed by the state of our TKIs. There will always be a small percentage of those of us with CML that don't respond, that have horrible side effects and, yes, new side effects will be revealed that weren't during testing. One thing we have to remember is that those of us on a TKI, even though it may be our whole world, are a very, very, very, very small subset of the population as a whole.
Also, those of us who actually post on this board are a very, very, very, very small subset of people with CML.
I don't think the sky is falling quite yet!
"You can't change the direction of the wind but you can adjust your sails."
DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>