See Hybrigenics gives update on chronic myeloid leukemia study
See also Combination of Inecalcitol with tyrosine kinase inhibitor
Hybrigenics gives update on chronic myeloid leukemia study
Started by
survenant
, Feb 21 2017 05:04 AM
Inecalcitol
6 replies to this topic
#2
missjoy
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Posted 22 February 2017 - 10:03 AM
Thank you servenant for posting the links. It sounds encouraging. Also see the link below.
http://www.bloodjour...so-checked=true
http://www.bloodjour...so-checked=true
#3
r06ue1
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Posted 22 February 2017 - 01:55 PM
Amazing that they continue to find all of these different paths to killing off LSC's. Just a matter of time before this cancer is scratched off the list.
survenant, do you have a Google alert set up or are you researching this stuff every day? 
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
#4
Trey
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Posted 23 February 2017 - 09:26 AM
Inecalcitol acts like a super Vitamin D3 which is more easily picked up by myeloid cells. The theory is this will make the myeloid cells (including leukemic stem cells) more susceptible to TKI drugs. For CML patients the results so far appear useful but not overly impressive.
#5
mdszj
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Posted 23 February 2017 - 04:50 PM
Trey
Not to change the subject but is vitamin D3 good for cml'ers, or even myeloma'ers to take?
dx cml 7/2012; 100 mg sprycel; splenectomy 9/2012; reached prcu 10/2013; dx smoldering myeloma 1/2015; 80 mg sprycel 12/2015; 50 mg sprycel 7/13/16; discontinued sprycel 11/15/16
#6
scuba
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Posted 23 February 2017 - 04:52 PM
Trey
Not to change the subject but is vitamin D3 good for cml'ers, or even myeloma'ers to take?
I look forward to Trey's response.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
#7
Trey
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Posted 24 February 2017 - 05:14 PM
All essential nutrients are good for anyone, including those with blood cancers. We need them, and they make us healthier overall, but they will not cure us of any blood cancer. Some here try to impute powers to vitamins which they do not have.
This Inecalcitol does not do anything of itself to kill leukemic cells. Oddly, buy docking in a D3 receptor it appears to make the leukemic cells act more like healthy cells so they will not rely on back door survival processes, then the TKI drugs may be able to kill them. But that is theory and the trials are not very convincing.
"Moderation in all things." -- Aristotle
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