Oncologist changed my medication from Sprycel to Gleevec because of chronic pleural effusion. Even though he reduced the Sprycel dosage down to 20mg every other day, I was still having bilateral thoracentesis every week. The hospital was removing 2 liters from the left and 1 liter from the right side.
I have been on 400mg of Gleevec for three weeks now and there is no reduction in the pleural effusion and I have a host of new side effects to deal with that I didn't have while on Sprycel. The edema is severe and I am a bit concerned with the volume of fluid throughout my body. Legs, feet, hands and face. Taking a diuretic does not seem to help because the fluid builds by the next morning.
Has anyone switched from Sprycel to Gleevec and seen a change in the Pleural Effusion side effect ?