6 replies to this topic

[Randall]

I'm a little scared because I got my results back and I went from 6% to 8%.  I went from Gleevec to Tasigna 2x/day 400 mg and now my doctor is going to be switching me to Sprycel.  He's also referring me to a bone marrow transplant specialist.  I'm a nervous wreck!!!!

[scuba]

Have you had a Chromosome mutation test - specifically to check for the t315i mutation. Before thinking about transplant you need to have your CML typed so you know what you have. It's important you find an Oncologist who is an expert in CML so you get the right treatment.

 

It is quite possible Sprycel will work for you. It is a very different drug from both Tasigna and Gleevec. Tasigna and Gleevec are structurally similar and work in a similar way although Tasigna binds more tightly to the response site. Sprycel binds to different sites and can usually work when the others don't. But it is important for you to find out.

[Randall]

I did have the mutation test after I was switched from Gleevec to Tasigna.  The test results showed no mutation.

[thatguy]

Is 6% the lowest you've gone? I'm with Scuba, go see a specialist if possible. ..how often do you test?

[Trey]

Your Onc is wise to do what he has done.  The drug switch is necessary, and the transplant consult is precautionary.  Sprycel has a reasonable chance to work for you, so that should be the primary focus.

[deva]

Why did you switch from Gleevec to Tasigna?

[r06ue1]

If Sprycel doesn't work for you try Bosulif, some have had good results from that switch.  If you fail Sprycel you also have the chance to get into the ABL001 trial which might do the trick.  

 

Avoid the transplant if possible.