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Delayed healing time?


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#1 thatguy

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Posted 20 December 2016 - 11:24 AM

Probably a stupid question, but does/has anybody experienced what they perceive as delayed healing of wounds, mouth sores, zits, etc?
3/25/2015- Dx'ed by FISH : 85% of cells dual-fusion signals, 7% with tri-fusion signals, WBC 212,000. Started Gleevec 400mg.... Calculated .93 SOKAL

08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)

#2 Liamsdad

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Posted 20 December 2016 - 03:15 PM

I cut and bleed much more easily now and it takes weeks for cuts to heal - so yes, with me I am experiencing longer healing times with cuts.


Diagnosed 10/02/2015

Started Gleevec 400 mg 10/29/2015

10/29/2015 - 105% IS 

01/28/2016 - 5.6% IS 

02/02/2016 - 1.31% IS 

04/21/2016 - 0.33% IS 

07/29/2016 - 0.36% IS

10/10/2016 - 0.26% IS

01/11/2017 - 0.16% IS

04/03/2017 - 0.037% IS

06/20/2017 - 0.020% IS

07/24/2017 - 0.34% IS - switching to Tasigna

10/26/2017 - 0.47% IS - off Tasigna and now being switched to Sprycel


#3 Trey

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Posted 20 December 2016 - 05:16 PM

Tendons and ligaments take longer to heal, especially with Gleevec.



#4 xxgirl

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Posted 20 December 2016 - 06:41 PM

thatguy - I definitely notice delayed healing time, with just about every bruise, cut and scratch I get.  

 

I attributed mine to my wonky blood counts, not sure if there is any correlation or not.  



#5 thatguy

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Posted 20 December 2016 - 07:39 PM

Thanks guys. Yeah XX, that's what puzzles me, since my counts have been normal (knocking on wood). I feel like cuts on my legs linger longer, I have a zit (for sure a zit) on my cheek that blew up enormous, and has been slowly reducing in size-but I've had it for like 2 months. Additionally, my mouth tissue seems more fragile, as sharp/hard foods rip me up pretty good...I'm at quite the odds with my appetite :(

Didn't know if this was another lavish frill of the "L" , tki, or just aging. Loving the day-glow shade of white skin I now sport though all summer months, too. That's fun.
3/25/2015- Dx'ed by FISH : 85% of cells dual-fusion signals, 7% with tri-fusion signals, WBC 212,000. Started Gleevec 400mg.... Calculated .93 SOKAL

08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)

#6 TeddyB

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Posted 22 December 2016 - 06:14 PM

Probably a stupid question, but does/has anybody experienced what they perceive as delayed healing of wounds, mouth sores, zits, etc?

 

Not a stupid question at all!

For me yes. Wounds take longer for me to heal.

I actually have one now that will not heal, not a proud moment for me, telling this here in the forum, but its located right next to my anus, and since that area is vulnerable once pr day during bathroom visits, the wound usually rips open.

Been like that for months now (4-5 months), bleeding on and off, asked my GP for help, gave me a cream of some sort, tried it, did not help much, maybe time to go visit her again :)



#7 Trey

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Posted 22 December 2016 - 07:54 PM

TB,

Maybe someone ripped you a new one.....just sayin'



#8 thatguy

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Posted 22 December 2016 - 09:20 PM

Oooof, that sounds excruciating. Im sure its a difficult area to heal under any circumstance. I wonder if sutures should be considered? No visit to a colorectal surgeon?
3/25/2015- Dx'ed by FISH : 85% of cells dual-fusion signals, 7% with tri-fusion signals, WBC 212,000. Started Gleevec 400mg.... Calculated .93 SOKAL

08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)

#9 tiredblood

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Posted 22 December 2016 - 11:15 PM

Tendons and ligaments take longer to heal, especially with Gleevec.



#10 tiredblood

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Posted 22 December 2016 - 11:17 PM

For a while now I've had what I think is, in layman's terms, called skiers thumb. I've been putting off having it seen about-- until I jam it into something and about go through the roof as a result of the unnerving pain.

We went to see the movie, Passengers. In the movie there is a Doctor pod that scans you and tells you how many health problems you have. I told my husband, it would tell me there is nothing wrong with you! Yes, that was sarcasm directed at the times we've all heard, "I don't think it is caused by your CML or TKI."

#11 Melanie

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Posted 23 December 2016 - 12:11 AM

Me too. My dermatologist, after freezing off several suspicious areas or cutting things off, always adds a couple extra weeks to the standard return time in the hopes I'll be closer to being healed on my return visit. Bruises take forever to go away.

Teddy B, maybe try keeping the sore coated with Vaseline. I had something similar, although different area and the Vaseline was the only thing that allowed it to heal. Took a while and not the most comfortable, but got the idea from what we do for our grandkids when they get a diaper rash. Hopefully it might work for you.
Dx - 05/2011; PCR: 15.04; Fish: 87% Slow responder due to pancytopenia. Current - Bosulif - Nov: 2012, Mar 2016 lowered to 300 mg. 07/16 back to 400 mg. Clinical trial drug, Promacta, Feb 2013, for low Platelets.
CyCR - Aug 2014, Positive for 1 chromosome Sep 2015. PCR: 12.77 in Oct, 2012 to 0.04 (MDA) in Mar, 2016. 4/2016 - 0.126 (Local lab (IS); 05/2016 - 0.195 (local); 6/2016 - 0.07 (MDA); 7/2016 - 0.03 (local) 9/13/2016 - 0.16 (MDA); 9/26/2016 - 0.31 (MDA); 11/2016 - 0.012 (local); 01/2017 - 0.24 (MDA); 04/2017 - 0.09 (MDA); Cytogenetics show der(1:7)(q10;p10)7 chromosome mutation. Repeat of Sep 2015. PCR - 6/2017- 0.035 (local); 10/2017- 0.02 (MDA)

#12 TeddyB

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Posted 23 December 2016 - 05:20 AM

TB,

Maybe someone ripped you a new one.....just sayin'

 

Indeed, just what i wanted for christmas :wub:

 

Oooof, that sounds excruciating. Im sure its a difficult area to heal under any circumstance. I wonder if sutures should be considered? No visit to a colorectal surgeon?

 

Its no fun at all, thats for sure. Yes, my doctor talked about making a small opening, remove any infections, inflamation etc clean it, and then suture it back up.

 

Me too. My dermatologist, after freezing off several suspicious areas or cutting things off, always adds a couple extra weeks to the standard return time in the hopes I'll be closer to being healed on my return visit. Bruises take forever to go away.

Teddy B, maybe try keeping the sore coated with Vaseline. I had something similar, although different area and the Vaseline was the only thing that allowed it to heal. Took a while and not the most comfortable, but got the idea from what we do for our grandkids when they get a diaper rash. Hopefully it might work for you.

 

Thank you for the tip, i might try it before going to my doctor again :)



#13 thatguy

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Posted 23 December 2016 - 10:49 AM

Something else that might help, Metamucil (taken far away, daily, from your tki) eliminate any straining.
3/25/2015- Dx'ed by FISH : 85% of cells dual-fusion signals, 7% with tri-fusion signals, WBC 212,000. Started Gleevec 400mg.... Calculated .93 SOKAL

08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)

#14 PhilB

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Posted 24 December 2016 - 11:44 AM

Something else that might help, Metamucil (taken far away, daily, from your tki) eliminate any straining.

I don't know which TKI TeddyB is on, but if it's Glivec they probably don't have an issue with straining.  More likely blast damage and/or shrapnel wounds.

 

As to the original question, when I went to half dosage the improvement in both my healing times and general skin fragility was dramatic.



#15 thatguy

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Posted 24 December 2016 - 02:19 PM

Lol, dear lord.
3/25/2015- Dx'ed by FISH : 85% of cells dual-fusion signals, 7% with tri-fusion signals, WBC 212,000. Started Gleevec 400mg.... Calculated .93 SOKAL

08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)

#16 Pin

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Posted 26 December 2016 - 04:26 PM

I have contstant inflammation and my injuries take ages to heal. I have tendonopathy and it takes forever (note it takes a long time in a regular person too) my heel is still sore from an injury sustained in April 2015. I get bursitis in places I didn't even know bursa existed (shins anyone?).

Good to know it can change with a reduction in dosage Phil, looking forward to testing that theory...

Diagnosed 9 June 2011, Glivec 400mg June 2011-July 2017, Tasigna 600mg July 2017-present (switched due to intolerable side effects, and desire for future cessation attempt).

Commenced monthly testing when MR4.0 lost during 2012.

 

2017: <0.01, <0.01, 0.005 (200mg Glivec, Adelaide) <0.01, 0.001 (new test sensitivity)

2016: <0.01, <0.01, PCRU, 0.002 (Adelaide)

2015: <0.01, <0.01, <0.01, 0.013

2014: PCRU, <0.01, <0.01, <0.01, <0.01

2013: 0.01, 0.014, 0.016, 0.026, 0.041, <0.01, <0.01 

2012: <0.01, <0.01, 0.013, 0.032, 0.021

2011: 38.00, 12.00, 0.14


#17 kat73

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Posted 27 December 2016 - 11:37 AM

As you can see, Thatguy, your answer is a whopping "yes!"  I can ditto your experience right on down the line.


Dx July 2009 on routine physical.  WBC 94.  Started Gleevec 400 mg Sept 2009.  MMR at 2yrs.  Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved.  Kidney issues developed because of Gleevec.  Switched to Sprycel 70 mg in Aug 2011.  Above side effects disappeared or improved.  Have been MR3.5 - 4.5 ever since.  Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017.  After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS.  Pleural effusion returned within a couple of months, same as before (moderate, left side only).  Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved.  At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.


#18 thatguy

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Posted 27 December 2016 - 07:53 PM

Good to know! Thanks
3/25/2015- Dx'ed by FISH : 85% of cells dual-fusion signals, 7% with tri-fusion signals, WBC 212,000. Started Gleevec 400mg.... Calculated .93 SOKAL

08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)




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