Some (uplifting) information from the Destiny trial.
I am considering asking my onc about lowering my dosage to 200mg gleevec pr day after around 6 years of full dosage (400mg), then maybe, just maybe come completely off after 4-5 years of half dose if numbers are on my side. I still have 1,5 years to think about starting half dose, but it does seem very tempting with all these uplifting study results coming out. My PCR has been hovering around 0,01 - 0,03 (IS), the last years, and then no detectable cml on my last test.
Some interesting outtakes from the article:
"After 12 months of half-dose therapy, molecular recurrence, defined as a loss of MR3 on two consecutive samples, was detected in 9 of 49 patients (18.4%) with MR3 but not MR4 remissions, compared with 3 of 125 patients (2.4%) with MR4 or better remissions"
From the Euroski study:
"As reported previously, patients who had been on a TKI for more than 5.8 years before attempting to stop had a lower rate of relapse (34.5%) than patients who had been on therapy for less than 5.8 years (57.4%). Each additional year of TKI therapy was associated with an approximately 16% better chance of successful TKI cessation."
Hope everyone is doing fine, and hope you have a great Christmas holiday