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Weight/BMI vs. dosage?


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#1 mscl

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Posted 07 November 2016 - 10:06 AM

Is there any correlation between our weight vs. our dosage? I recently lost 20 pounds (on purpose, not because of CML, but because I needed to). I developed a bad skin rash and wondering if dosage can be too strong at any point.
Dx 2/10/12.
Sprycel 100. mg.
10/2015, Pleural effusions, both sides, about a 3-4 week break in Rx, reduced to 70 mg.
PEs, weren't completely gone, started building back up, about a 6-8 week break in Rx.
01/2016, Reduced to sprycel 50 mg.
10/2016, developed severe skin rash, mainly upper arms and upper legs, smaller rashes on lower arms, lower legs, upper back/neck. Rx break of about 6 weeks.
1/25/17, reduced to Sprycel 20 mg.
7/19/17, still at 20 mg Sprycel, undetectable.
11/9/17, 20 mg Sprycel, undetectable.

#2 Trey

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Posted 07 November 2016 - 08:25 PM

If you needed to lose the weight, there is no correlation.

 

Said another way, the correlation would be dosage per ml of blood, not per gram of fat.

 

But a loss of lipids could increase skin sensitivity and rashes. 

http://www.justabout...s-in-skin-care/



#3 mscl

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Posted 07 November 2016 - 08:45 PM

Thanks Trey! You are such a wealth of knowledge and such a great asset to this forum!
Dx 2/10/12.
Sprycel 100. mg.
10/2015, Pleural effusions, both sides, about a 3-4 week break in Rx, reduced to 70 mg.
PEs, weren't completely gone, started building back up, about a 6-8 week break in Rx.
01/2016, Reduced to sprycel 50 mg.
10/2016, developed severe skin rash, mainly upper arms and upper legs, smaller rashes on lower arms, lower legs, upper back/neck. Rx break of about 6 weeks.
1/25/17, reduced to Sprycel 20 mg.
7/19/17, still at 20 mg Sprycel, undetectable.
11/9/17, 20 mg Sprycel, undetectable.

#4 Trey

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Posted 09 November 2016 - 02:21 PM

Some people just drop the "et" from "asset".  I never knew that was what it meant, so thanks.






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