Anybody taking both? My BP has been on a steady incline this past year...I have had periods of higher bp prior to CML diagnosis 3 years ago. Once on Sprycel, numbers declined to 120/75-80. Now, i am looking at 160/87-90. Lisinopril gives me cough...doc wants to try Losartan. Anybody else on both? What has worked?
High blood pressure meds and Sprycel
Started by
DebDoodah22
, Oct 30 2016 02:45 PM
6 replies to this topic
#2
Trey
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Posted 30 October 2016 - 06:13 PM
Losartan is an angiotensin II receptor antagonist (constricts the blood vessels) and is recommended as first-line treatment in patients under 55 who do not tolerate an ACE inhibitor such as Lisinopril. But if you have edema from the Sprycel a diuretic such as Lasix might be a better approach for lowering blood pressure, but ask your docs.
http://www.webmd.com...---oral/details
Edited by Trey, 30 October 2016 - 06:17 PM.
#3
CMLParent
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Posted 30 October 2016 - 10:44 PM
My son was on a Clonidine patch as well as Amlodipine for high blood pressure while on Sprycel.
Amlodipine is a calcium channel blocker which caused a CYP 3A4 inhibition by Dastinib. This increased the exposure of Amlodipine so he needed very little of it to control his blood pressure. Other than that we did not notice any issues while he was taking these medications.
Amlodipine is a calcium channel blocker which caused a CYP 3A4 inhibition by Dastinib. This increased the exposure of Amlodipine so he needed very little of it to control his blood pressure. Other than that we did not notice any issues while he was taking these medications.
#4
hannibellemo
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Posted 31 October 2016 - 06:13 AM
I have isolated systolic high blood pressure. The trick was getting my systolic below 140 while not tanking my diastolic which is always in the low 60s and sometimes below. Dyazide didn't do the the trick, lisinopril at various levels with HTZ always tanked my diastolic and I felt like crap. 10mg. of lisinopril (I don't have the cough) seems to do the trick.
Good luck.
Pat
"You can't change the direction of the wind but you can adjust your sails."
DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>
#5
AdamJ
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Posted 03 November 2016 - 06:21 AM
I have been taking Amlodipine with Sprycel for several months now. I have noticed that my blood pressure has been more stable than it used to be. Can you tell me what dosage of Amlodipine he was taking? I am wondering if I should look into reducing from 5mg to 2.5mg.
My son was on a Clonidine patch as well as Amlodipine for high blood pressure while on Sprycel.
Amlodipine is a calcium channel blocker which caused a CYP 3A4 inhibition by Dastinib. This increased the exposure of Amlodipine so he needed very little of it to control his blood pressure. Other than that we did not notice any issues while he was taking these medications.
3/23/2016 Dx PCR 93.4399% IS, FISH 87%
3/30/16 Sprycel 100mg
4/15/2016 liver toxicity and a brief stint on Tasigna 600mg book-ended by drug breaks
6/6/2016 resumed Sprycel at 50 mg increased to 70 one month later followed by 100mg
6/17/2016 FISH Test 2%
8/22/2016 PCR 0.0035% IS
11/7/2016 PCRU
12/29/2016 PCRU
4/5/2017 PCRU
6/28/2017 PCRU
10/26/2017 PCRU
#6
CMLParent
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Posted 03 November 2016 - 07:15 AM
Hi Adam,
His dose was 1.5 mg.
His dose was 1.5 mg.
#7
AdamJ
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Posted 03 November 2016 - 08:33 AM
Thank you, that is very helpful. I will ask about a lower dose when I visit the doctor next.
Hi Adam,
His dose was 1.5 mg.
3/23/2016 Dx PCR 93.4399% IS, FISH 87%
3/30/16 Sprycel 100mg
4/15/2016 liver toxicity and a brief stint on Tasigna 600mg book-ended by drug breaks
6/6/2016 resumed Sprycel at 50 mg increased to 70 one month later followed by 100mg
6/17/2016 FISH Test 2%
8/22/2016 PCR 0.0035% IS
11/7/2016 PCRU
12/29/2016 PCRU
4/5/2017 PCRU
6/28/2017 PCRU
10/26/2017 PCRU
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