Jump to content


Photo

Platelets


  • Please log in to reply
7 replies to this topic

#1 stpaddy

stpaddy

    Member

  • Members
  • PipPip
  • 13 posts

Posted 25 October 2016 - 04:43 PM

Hi Everyone,

 

This is my first time posting to the board - so happy to have found it!

 

My husband was diagnosed with CML this past March and has been on 400mg Gleevec since April.  He had a 1.6 log reduction at 3 mos and we are currently waiting for the 6 mo result.  We noticed however that his platelets seem to be slowly increasing and just wondered if this is something we should be worried about.

 

At diagnosis, his platelets were 395 and they came down to 299 by the end of May.  They have been steadily rising each month since and are currently at 366.  The bloodwork report says the normal range is 150 - 400 x 10 9/L so we are still normal but just wondering what happens if they keep rising.

 

Thank you for any info...

 



#2 Trey

Trey

    Advanced Member

  • PS Beta Group
  • PipPipPip
  • 1,705 posts
  • LocationSan Antonio, Texas

Posted 26 October 2016 - 08:47 AM

Short term trends like this do not necessarily imply the rise in platelets will continue.  His platelets are normal, so that is good.  I would not be concerned about it unless the Platelet count would get above maybe 600, which is unlikely.  He is in his first year, so the blood counts wil usuallyl not be "normal" as with the general population of people without CML. 

 

Also, the platelet counts are variable.  Platelets do not simply remain in the blood, but the spleen sequesters many of them until there is a bleeding which needs to be clotted.  So platelet counts can vary significantly as the spleen holds more or releases more into the blood.



#3 hannibellemo

hannibellemo

    Advanced Member

  • Members
  • PipPipPip
  • 728 posts
  • LocationNorth Central Iowa

Posted 26 October 2016 - 01:30 PM

stpaddy,

 

Glad you found us, too; welcome! I find worrying about a loved one is much worse then worrying about myself so I hope you find us to be a safe haven for your concerns about your husband. 

 

Good luck!


Pat

 

"You can't change the direction of the wind but you can adjust your sails."

DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>


#4 stpaddy

stpaddy

    Member

  • Members
  • PipPip
  • 13 posts

Posted 26 October 2016 - 05:15 PM

Thank you both so much.   That is extremely helpful info & much appreciated! 


Husband dx March 2016; 400mg Gleevec started April 2016;

July 2016 PCR 3.06% 

Oct 2016 PCR 0.002%

Jan 2017 PCR 0.004%

April 4, 2017 PCR 0.001%

Reduced to 300mg Gleevec at end of April 2017 due to fatigue   

July 2017 PCR 0.001%

Oct 3, 2017 PCR 0.001%

Oct 18, 2017 PCR 0.003%

Dec 19, 2017 PCR 0.001%


#5 beno

beno

    Advanced Member

  • Members
  • PipPipPip
  • 92 posts
  • LocationIowa

Posted 28 October 2016 - 12:12 PM

This board has been very helpful for me as well.  I'd be happy that your husband has good platelet counts.  Mine were under 100 for the first couple months of treatment and got as low as 12.


DX 3/30/2016 WBC 484.2 FISH 95.3

took Hydrea 3/30-4/11

taking Sprycel 100 mg since 4/5

10 day break from Sprycel for platelet count of 12 4/26-5/8

7/07/2016 1.47% (IS)

9/30/16 BMB PCR .1259 switched to new onc

12/30/16 PCR .1569

4/7/17 PCR .0904 MMR

7/14/17 PCR .0520

12/1/17 PCR .0148


#6 mscl

mscl

    Advanced Member

  • Members
  • PipPipPip
  • 68 posts
  • LocationSalina KS

Posted 28 October 2016 - 03:05 PM

I've always been on the very low end of normal. That's my new normal.
Dx 2/10/12.
Sprycel 100. mg.
10/2015, Pleural effusions, both sides, about a 3-4 week break in Rx, reduced to 70 mg.
PEs, weren't completely gone, started building back up, about a 6-8 week break in Rx.
01/2016, Reduced to sprycel 50 mg.
10/2016, developed severe skin rash, mainly upper arms and upper legs, smaller rashes on lower arms, lower legs, upper back/neck. Rx break of about 6 weeks.
1/25/17, reduced to Sprycel 20 mg.
7/19/17, still at 20 mg Sprycel, undetectable.
11/9/17, 20 mg Sprycel, undetectable.

#7 RayT

RayT

    Advanced Member

  • Members
  • PipPipPip
  • 42 posts
  • LocationSyracuse NY

Posted 03 November 2016 - 05:53 PM

I had my spleen removed 34 years ago due to staging for Hodgkins Disease. I've chronically run platlet counts in the 500s since then with no problem. I had a heart attack due to the chemo for Hodgkins in 1985. My cardiologist has me on aspirin 325mg/day to help thin my blood. You're fine...:-)

#8 RayT

RayT

    Advanced Member

  • Members
  • PipPipPip
  • 42 posts
  • LocationSyracuse NY

Posted 03 November 2016 - 05:54 PM

I had my spleen removed 34 years ago due to staging for Hodgkins Disease. I've chronically run platlet counts in the 500s since then with no problem. I had a heart attack due to the chemo for Hodgkins in 1985. My cardiologist has me on aspirin 325mg/day to help thin my blood. You're fine...:-)




1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users