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tasigna and ketoprofen

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#1 Lucas


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Posted 11 October 2016 - 09:14 AM

hey, guys!! is there any known interaction between tasigna and ketoprofen? thanks in advance!

#2 hannibellemo


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Posted 12 October 2016 - 06:17 AM

Lucas, you can check that out on http://www.drugs.com



"You can't change the direction of the wind but you can adjust your sails."

DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>

#3 Lucas


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Posted 13 October 2016 - 04:04 PM

Thank you, hannibellemo!!!

#4 jlegakis


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Posted 15 October 2016 - 03:10 PM

Does Tasigna interact with alcohol? My liver ALT went up steadily since I started Tasigna 6 wks. ago as I am drinking 2-3 glasse of wine every night.My creatine tests are fine and all my blood counts are in the normal range, so I was wondering about alcohol- should I stop drinking or is my liver just trying to adjust to my new regimen of 800 mg. of Tasigna daily? I also was taking Ibuprofen 800mg. occasionally for sore muscles ,since I run a lot.Could that be the problem too ? I drank and took Ibuprofen when I was on Gleevec and Sprycel and all my liver counts were LOW! 

#5 Buzzm1


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Posted 15 October 2016 - 06:20 PM

alcohol tasigna effect on the liver

For the benefit of yourself and others please add your CML history into your Signature


02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive


2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17


At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  


In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  


longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.


Cumulative Gleevec dosage estimated at 830 grams


Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  


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#6 Trey


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Posted 22 October 2016 - 12:37 PM

None of the TKI drugs interact with alcohol, but they are processed by the liver so if the liver is stressed by too much work it can get cranky.  Tasigna by itself causes ALT & AST to rise, often for no reason other than a reaction.  It usually does not indicate liver damage.  But if the ALT & AST double, then a drug break is often needed.  And drinking alcohol should be restricted if the doubling occurs.  Otherwise I would not be too concerned about drinking moderately while taking TKI drugs.

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