Combination of EZH2 inhibitors with tyrosine kinase inhibitors may offer cure without need for long-term treatmentEZH2 inhibitors cml
Posted 10 October 2016 - 11:51 PM
I have a question. Do the higher order stem cells pump out healthy cells as well as cancerous cells? Or do we have hscs that are completely healthy and thus keep us with enough normal WBCs to fight infection? If we destroy the cml hscs are they replaced? Curious about these stem cells!
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
Posted 12 October 2016 - 08:24 AM
Patients with CML have two lines of blood stem cells, a healthy line and a leukemic line. The TKI drugs kill off the leukemic cell line up to a certain level, but not all the way to the top. It is unknown where the top level of the CML leukemic line of blood stem cells begins, but it is the highest of any of the leukemias.
Posted 12 October 2016 - 08:56 AM
Leukemic stem cell origin (hypothesis):
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users