Combination of EZH2 inhibitors with tyrosine kinase inhibitors may offer cure without need for long-term treatment
Started by
survenant
, Oct 10 2016 04:21 PM
EZH2 inhibitors cml
3 replies to this topic
#2
Gail's
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Posted 10 October 2016 - 11:51 PM
Thanks for the link survenant. The article in Cancer Network spoke in terms of prolonged survival and better combo drugs for those resistant to TKIs alone. Seemed to me they were more cautious about claiming it as a cure. I suppose until they see drug trials.
I have a question. Do the higher order stem cells pump out healthy cells as well as cancerous cells? Or do we have hscs that are completely healthy and thus keep us with enough normal WBCs to fight infection? If we destroy the cml hscs are they replaced? Curious about these stem cells!
I have a question. Do the higher order stem cells pump out healthy cells as well as cancerous cells? Or do we have hscs that are completely healthy and thus keep us with enough normal WBCs to fight infection? If we destroy the cml hscs are they replaced? Curious about these stem cells!
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#3
Trey
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Posted 12 October 2016 - 08:24 AM
Patients with CML have two lines of blood stem cells, a healthy line and a leukemic line. The TKI drugs kill off the leukemic cell line up to a certain level, but not all the way to the top. It is unknown where the top level of the CML leukemic line of blood stem cells begins, but it is the highest of any of the leukemias.
#4
scuba
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Posted 12 October 2016 - 08:56 AM
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
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