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Sprycel Change

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#1 r06ue1


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Posted 07 October 2016 - 05:47 AM

My Oncologist offered to switch me from Gleevec (brand name) to Sprycel, just wanted to get others thoughts.  


My PCR has been going down so that is not the concern, have had side effects but they have been manageable.  I was considering it since I want to hit PCRU and also because of the cost next year with Gleevec perhaps not having the co-pay card and Sprycel's still available which could save me thousands.  Oncologist wants to put me on 100 mg but I was thinking I might cut them in half.  


What do you all think?  I was going to do it but wanted to get others opinions first.



08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%



Taking Imatinib 400 mg

#2 Billie Murawski

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Posted 09 October 2016 - 02:55 AM

Hi Ro, I was so sick on Gleevac(3 years) I practically begged my onc. to put me on Sprycel. So he started me on 100mg Sprycel now I have worked my way down to 20mg after 4 years and 2 years later I'm still 0% I do have some problems with fatigue and fluid around my lungs  but I've learned how to handle it. Always take a water pill and take a 3or4 day break from Sprycel. I can't tell you about the fatigue (because I'm older than dirt) But all my life I have had problems with pneumonia,bronchitus, etc. so I think I'm prone to these problems anyway. I would rather tolerate Sprycel side-effects than Gleevac or any other tki. Good Luck Billie

#3 kat73


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Posted 09 October 2016 - 04:13 PM

I second Billie, in that I, too, was sick as the proverbial dog the whole 2 years I was on Gleevec; felt 100% better on Sprycel.  I've had two small pleural effusions that nobody felt needed treatment or Sprycel stoppage.  Fatigue is a problem, but it seems to be on any of the TKIs.  I don't contend with nearly the puffiness that I did on Gleevec.  Good luck!

Dx July 2009 on routine physical.  WBC 94.  Started Gleevec 400 mg Sept 2009.  MMR at 2yrs.  Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved.  Kidney issues developed because of Gleevec.  Switched to Sprycel 70 mg in Aug 2011.  Above side effects disappeared or improved.  Have been MR3.5 - 4.5 ever since.  Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017.  After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS.  Pleural effusion returned within a couple of months, same as before (moderate, left side only).  Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved.  At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.

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