See Prospect of shorter treatment and cure for chronic myelogenous leukemia
See also Cure possible for CML?
Prospect of shorter treatment and cure for chronic myelogenous leukemia
Started by
survenant
, Sep 15 2016 11:01 AM
CML cure Leukemia
13 replies to this topic
#2
scuba
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Posted 15 September 2016 - 11:45 AM
Combination therapy is growing in importance as a viable avenue in cancer "cure" research. In the article linked above, the pathway discovered, which may control leukemic stem cell survival, is described here:
http://www.nature.co...ll/nm.4036.html
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
#3
r06ue1
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Posted 15 September 2016 - 11:57 AM
Similar path to the one taken by the University of Glasgow researchers and their cure.
I keep tabs on the clinical trials for CML and nothing new as of today which would benefit those of us on the boards. Seems all of the immunotherapy trials in the US are targeting people that have had or will have a SCT or its side effects (GVHD). We will just have to wait our turn.
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
#4
rcase13
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Posted 15 September 2016 - 12:58 PM
But i don't want to wait... 
In my best 2 year old tantrum...
10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)
01/02/2015 0.06% Tasigna 600mg
04/08/2015 0.01% Tasigna 600mg
07/01/2015 0.01% Tasigna 600mg
10/05/2015 0.02% Tasigna 600mg
01/04/2016 0.01% Tasigna 600mg
04/04/2016 PCRU Tasigna 600mg
07/18/2016 PCRU Tasigna 600mg
10/12/2016 PCRU Tasigna 600mg
01/09/2017 PCRU Tasigna 600mg
04/12/2017 PCRU Tasigna 600mg
10/16/2017 PCRU Tasigna 600mg
01/15/2018 PCRU Tasigna 600mg
Cancer Sucks!
#5
kat73
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Posted 15 September 2016 - 03:42 PM
Yeah, me neither. But what I want to know is, what else does this EZ stuff kill? Also, what about our perennial problem - how do you know you've killed all the stem cells?
Dx July 2009 on routine physical. WBC 94. Started Gleevec 400 mg Sept 2009. MMR at 2yrs. Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved. Kidney issues developed because of Gleevec. Switched to Sprycel 70 mg in Aug 2011. Above side effects disappeared or improved. Have been MR3.5 - 4.5 ever since. Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017. After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS. Pleural effusion returned within a couple of months, same as before (moderate, left side only). Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved. At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.
#6
scuba
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Posted 15 September 2016 - 04:39 PM
Yeah, me neither. But what I want to know is, what else does this EZ stuff kill? Also, what about our perennial problem - how do you know you've killed all the stem cells?
Only stopping medication for many years and having no bcr-abl detected by PCR would give confidence that CML has been 'cured'. And even then, we would not know if the cure is permanent or just until another instance of CML gets started. Only an immune boosting therapy where any new instance of CML is immediately targeted by the body on its own would be a true cure. A 'vaccine' against CML is where true cure lies.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
#7
kat73
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Posted 16 September 2016 - 01:49 PM
Would EZH2 only attack CML stem cells and nothing else?
Dx July 2009 on routine physical. WBC 94. Started Gleevec 400 mg Sept 2009. MMR at 2yrs. Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved. Kidney issues developed because of Gleevec. Switched to Sprycel 70 mg in Aug 2011. Above side effects disappeared or improved. Have been MR3.5 - 4.5 ever since. Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017. After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS. Pleural effusion returned within a couple of months, same as before (moderate, left side only). Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved. At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.
#8
Gail's
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Posted 17 September 2016 - 04:24 PM
I'm curious about what killing off the defective stem cells would do to blood counts. I envision healthy stem cells would quickly begin to fill in as the bad ones die off. But would there be an interval of time with problems till the good cells catch up?
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#9
Tucker1
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Posted 17 September 2016 - 08:27 PM
Scuba, I am curious. What do you mean when you say "another instance of CML gets started."
Dx: 11/2004 intermediate risk 400 mg Gleevec
11/2005 partial cytogenetic response PCR 6.3
Clinical trial Sprycel 50mg 2x daily 12/05
11/06 PCR weak positive
10/07 PCR undetectable
12/08 PCR .017
Recurring colitis from Sprycel
11/09 Tasigna PCR .0075 200 mg 2x daily
11/10 PCR .078 400 mg 2x daily
11/11PCR weak positive
2/12 PCR. .15 decrease 200 mg 2x (QT prolongation)
Dosage changes until 2015 QT recurrent PCR .004
7/15 bosulif 500 mg
Liver toxicity discontinued bosulif PCR .025
Restart bosulif 100mg
12/15 PCR .714
Increase bosulif slowly
2/16 PCR.5
5/16 PCR .000 bosuitinib 400mg
8/16 PCR .027 Bosuitinib 300mg
10/16 PCR .117 Bosuitinib 300mg
1/17 PCR .243 Bousitinib 300mg
4/17 PCR .403
11/2005 partial cytogenetic response PCR 6.3
Clinical trial Sprycel 50mg 2x daily 12/05
11/06 PCR weak positive
10/07 PCR undetectable
12/08 PCR .017
Recurring colitis from Sprycel
11/09 Tasigna PCR .0075 200 mg 2x daily
11/10 PCR .078 400 mg 2x daily
11/11PCR weak positive
2/12 PCR. .15 decrease 200 mg 2x (QT prolongation)
Dosage changes until 2015 QT recurrent PCR .004
7/15 bosulif 500 mg
Liver toxicity discontinued bosulif PCR .025
Restart bosulif 100mg
12/15 PCR .714
Increase bosulif slowly
2/16 PCR.5
5/16 PCR .000 bosuitinib 400mg
8/16 PCR .027 Bosuitinib 300mg
10/16 PCR .117 Bosuitinib 300mg
1/17 PCR .243 Bousitinib 300mg
4/17 PCR .403
#10
Trey
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Posted 17 September 2016 - 09:51 PM
EZH2 (Enhancer of Zeste) plays an essential role in development, cell differentiation, and cell division. So I would want to know the downside of inhibiting EZH2 before getting too excited.
But I think it would be really cool to be known as the Enhancer of Zeste. Probably would need to live in a castle or something. Maybe Herstmonceux west of London would be nice. Car license plate would be EZH2. Coat of Arms would be a lemon peel zester with a Roman machaira sword through the middle section and a puking dragon sitting on top. Family motto would be "The World Is Not Enough" unless it is already taken...maybe it is. Anyway, it would be a really cool title.
Edited by Trey, 18 September 2016 - 09:25 AM.
#11
scuba
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Posted 18 September 2016 - 12:38 PM
Scuba, I am curious. What do you mean when you say "another instance of CML gets started."
A true cure can only occur if our bodies are taught ( through immune response by immunization) to destroy CML cancer cells as they emerge. Even if all leukemic stem cells are eradicated with new treatments emerging, the chance a new leukemic stem cell could form once the drugs are stopped is still possible. The 9 and 22 chromosome are tightly bound right at the bcr-abl breakpoints. It's any wonder that more CML doesn't occur. But the reality is (M.D. Anderson, pers. comm.) Leukemic stem cells are forming all of the time - naturally and with help (i.e. radiation, carcinogens). We develop CML, the disease, because our immune systems are either overwhelmed and not able to keep up with the dividing CML cells or not able to recognize the cells in the first place as "bad".
We probably would not know easily whether our original CML relapsed (i.e. not all LSC's were destroyed) or whether a new instance of CML initiated (i.e. a normal blood stem cell divides into a new LSC with philadelphia chromosomes). Since we developed the disease once, I suspect we're susceptible to LSC formation again.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
#12
Tucker1
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Posted 18 September 2016 - 03:17 PM
Scuba thanks for making that clear to me. I continue to read about CML I guess wondering if my radiation treatment for breast cancer got the ball rolling. Sounds like the odds are good. Thanks again Tucker1
Dx: 11/2004 intermediate risk 400 mg Gleevec
11/2005 partial cytogenetic response PCR 6.3
Clinical trial Sprycel 50mg 2x daily 12/05
11/06 PCR weak positive
10/07 PCR undetectable
12/08 PCR .017
Recurring colitis from Sprycel
11/09 Tasigna PCR .0075 200 mg 2x daily
11/10 PCR .078 400 mg 2x daily
11/11PCR weak positive
2/12 PCR. .15 decrease 200 mg 2x (QT prolongation)
Dosage changes until 2015 QT recurrent PCR .004
7/15 bosulif 500 mg
Liver toxicity discontinued bosulif PCR .025
Restart bosulif 100mg
12/15 PCR .714
Increase bosulif slowly
2/16 PCR.5
5/16 PCR .000 bosuitinib 400mg
8/16 PCR .027 Bosuitinib 300mg
10/16 PCR .117 Bosuitinib 300mg
1/17 PCR .243 Bousitinib 300mg
4/17 PCR .403
11/2005 partial cytogenetic response PCR 6.3
Clinical trial Sprycel 50mg 2x daily 12/05
11/06 PCR weak positive
10/07 PCR undetectable
12/08 PCR .017
Recurring colitis from Sprycel
11/09 Tasigna PCR .0075 200 mg 2x daily
11/10 PCR .078 400 mg 2x daily
11/11PCR weak positive
2/12 PCR. .15 decrease 200 mg 2x (QT prolongation)
Dosage changes until 2015 QT recurrent PCR .004
7/15 bosulif 500 mg
Liver toxicity discontinued bosulif PCR .025
Restart bosulif 100mg
12/15 PCR .714
Increase bosulif slowly
2/16 PCR.5
5/16 PCR .000 bosuitinib 400mg
8/16 PCR .027 Bosuitinib 300mg
10/16 PCR .117 Bosuitinib 300mg
1/17 PCR .243 Bousitinib 300mg
4/17 PCR .403
#13
LAC1223
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Posted 20 September 2016 - 09:44 AM
Scuba thanks for making that clear to me. I continue to read about CML I guess wondering if my radiation treatment for breast cancer got the ball rolling. Sounds like the odds are good. Thanks again Tucker1
I was just thinking about the same thing Tucker1 - that the Radiation I had for my Brain Tumor got the ball rolling for me. Got excited when I first read on the EZH1, but of course, it's a cautionary tale. Now, I just continue the fight of CVS Caremark denying my Sprycel coverage - so ironic that I have to fight to get covered for a medicine that I really don't want to take, if I could just go POOF and the CML would go away.
#14
rcase13
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Posted 21 September 2016 - 05:15 AM
Having similar issues with Tasigna and CVS Pharmacy. They denied my recent refill request. Hoping the doctor's can work it out for me.
10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)
01/02/2015 0.06% Tasigna 600mg
04/08/2015 0.01% Tasigna 600mg
07/01/2015 0.01% Tasigna 600mg
10/05/2015 0.02% Tasigna 600mg
01/04/2016 0.01% Tasigna 600mg
04/04/2016 PCRU Tasigna 600mg
07/18/2016 PCRU Tasigna 600mg
10/12/2016 PCRU Tasigna 600mg
01/09/2017 PCRU Tasigna 600mg
04/12/2017 PCRU Tasigna 600mg
10/16/2017 PCRU Tasigna 600mg
01/15/2018 PCRU Tasigna 600mg
Cancer Sucks!
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