Hi, After a failed attempt at treatment free after 4 yrs on Tasigna and PCRU for all that time, the CML specialist has suggested my 72 yr old husband try 70 mg Sprycel (once daily) instead. My husband maintained PCRU on Tasigna at somewhat reduced dose (200 mg x 2 daily) the last 2 years he was on it. He was considered good candidate for TFR, but his PCR went up right away to .03 and then 1.2. He went off Tasigna (which he tolerated well, especially at the lower dose) specifically because of concerns about vascular occlusive events and other long term toxicity. Returning to an even lower dose of Tasigna, eg, 200 mg per day, is not an option due to onc wanting to get him back to MMR quickly. MY MAIN QUESTION: Has anyone NOT had pleural effusions on Sprycel at 70 mg? I have read so many horror stories. AND, are there ways to monitor and catch it before it gets bad....or suggestions how to avoid this side effect that appears to affect at least 28% of those on sprycel and perhaps more, especially given his age. Any other suggestions from experienced sprycel users?
We had high hopes for TFR and are disappointed, but know how lucky we are there are these other options.
Appreciate input....being "high info" person, i will feel better after hearing from others.