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The Arrival of Generic Imatinib Into the U.S. Market: An Educational Event


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#1 Buzzm1

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Posted 13 July 2016 - 11:43 AM

The Arrival of Generic Imatinib Into the U.S. Market: An Educational Event http://bit.ly/29XQxrj

 
Imatinib was priced at $26,000/year in 2001, a price that considered the population at risk, the cost of research, and profits envisioned for a successful company market strategy. The price was described then as "high but fair" by Daniel Vasella, Chairman and CEO of Novartis.1 The price of imatinib has increased by 10%-20% annually, reaching $132,000/year in 2014 and $146,000/year today (Table 1 on page 111).2 Global sales of patented imatinib were about $4.7 billion in 2015.
 
The advent of generic imatinib into the U.S. market educates us on several important points relevant to cancer care today: (1) the high cancer drug prices (previously detailed in several publications)4-6; (2) the importance of generics for patient care and to reduce drug prices; and (3) how well-intended legislations like the Hatch-Waxman Act can be distorted by drug companies to maximize profits.
 

For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt


#2 r06ue1

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Posted 13 July 2016 - 11:59 AM

I would hope to see the generic prices decline to where Imatinib first began but after Sun's product release, I have a funny feeling that there is going to be some collusion (a cartel) to keep the prices as high as possible.


08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%

 

 

Taking Imatinib 400 mg


#3 Buzzm1

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Posted 13 July 2016 - 07:49 PM

We know that Sun Pharma loses its six-month sole proprietorship of U.S. generic Imatinib on August 1; it's going to be interesting to see if the price drops, and by how much, beyond that point.  Congress, and the FDA, are in the back pocket of Big PhRMA, so I'll be surprised if there is a monumental decrease in price anytime soon.  

 

In the article, the current price of Gleevec is quoted at $146K/yr..  I again checked here and it's still $11K/mo. ($132K/yr.) so I don't know where Dr. Kantarjian is getting his price quote. The article also states "When generic imatinib finally entered the U.S. market in February 2016, it was priced at about $140,000/year." I priced U.S. generic Imatinib Mesylate at $124K/yr.

 

​From the article "Today, health care is globalized, and there are more than 18 generic imatinib versions available worldwide, including 3 in Canada. Generic imatinib is sold at $8,800/year in Canada and at about $400/year in India. The cost to manufacture a 1-year supply of 400-mg imatinib tablets is $159. Two years from now, the price of generic imatinib in the United States (or purchased from abroad) will be significantly lower, hopefully less than $1,000/year."


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt





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