Advanced Member
Posted 10 June 2016 - 05:23 AM
I heard today that scientists at Glasgow university have discovered 2 proteins that keep CML stem cells alive (p53 and CMyC. They have discovered a drug combination that can kill these two. They have apparently successfully eradicated CML in lab mice, reducing the stem cells by over 88% in a few weeks with the drugs. Apparently they are starting human trials. This could be huge.
Alex
Advanced Member
Posted 10 June 2016 - 07:59 AM
Wow ! Man I hope this is true! I'll be praying, I'm getting all excited I know its early but the thought of not having to pay for medicine when we retire ! Game changer!
LOL
Have a good weekend All !
Cathy
DX 5-2010 Started normal hydra then Gleevec for 9 months stopped working
Tasigna after 5 pills pancreatis numbers jumped up quickly
Started Sprycel 100, 8-2010 for a 3 years went down to 50 mg numbers at one point really jumped up quickly
currently on 70 mg for last 2-3 years trying to get onc to reduce dose Numbers never stabilize never MMR till 4-2017 bearly and jump up and down in and out of MMR stayed MMR for 3 months then
After 6 years on sprycel fluid on both lungs, drained still have some fluid on lungs, and currently off drug 4 months now
numbers lower then ever go figure I've never been this low of a number
last 2 tests .0686 and .0181 !!
Advanced Member
Posted 10 June 2016 - 08:22 AM
Hehe, third post on the subject but good news no matter how many times it is said. 
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
Advanced Member
Posted 10 June 2016 - 10:07 AM
My excitement level just dropped after reading a bit on p53:
p53 has many mechanisms of anticancer function and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis. In its anti-cancer role, p53 works through several mechanisms:
- It can activate DNA repair proteins when DNA has sustained damage. Thus, it may be an important factor in aging.[29]
- It can arrest growth by holding the cell cycle at the G1/S regulation point on DNA damage recognition (if it holds the cell here for long enough, the DNA repair proteins will have time to fix the damage and the cell will be allowed to continue the cell cycle).
- It can initiate apoptosis (i.e., programmed cell death) if DNA damage proves to be irreparable.
I'm no molecular biologist (not even close, hated biology in school) but to me, it sounds like supressing p53 could lead to more cancer(s). Unless the drug specifically targets a mutated version of p53 that is.
https://en.wikipedia.org/wiki/P53
Myc (c-Myc) looks more promising as it has been known to cause many cancers:
Myc (c-Myc) is a regulator gene that codes for a transcription factor. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation.[1]
A mutated version of Myc is found in many cancers, which causes Myc to be constitutively (persistently) expressed. This leads to the unregulated expression of many genes, some of which are involved in cell proliferation, and results in the formation of cancer.[1] A common human translocation involving Myc is critical to the development of most cases of Burkitt lymphoma.[2] Malfunctions in Myc have also been found in carcinoma of the cervix, colon, breast, lung and stomach.[1] Myc is thus viewed as a promising target for anti-cancer drugs.[3]
https://en.wikipedia.org/wiki/Myc
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
Advanced Member
Posted 10 June 2016 - 10:27 AM
"Unless the drug specifically targets a mutated version of p53 that is. "
That is what the drug does ...
It's when P53 goes 'bad' that we have problems.
http://www.ncbi.nlm....les/PMC3135636/
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
Advanced Member
Posted 10 June 2016 - 10:49 AM
Interesting points. We need a lot more info. I'm definitely going to bring this up next onc visit. Scuba, be sure and tell us what Dr. Cortes says. In the meantime, here's a lighthearted question: say suppressing p53 cures your CML, but makes you REALLY OLD REALLY FAST? Would you take it? Hmmmm.
Dx July 2009 on routine physical. WBC 94. Started Gleevec 400 mg Sept 2009. MMR at 2yrs. Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved. Kidney issues developed because of Gleevec. Switched to Sprycel 70 mg in Aug 2011. Above side effects disappeared or improved. Have been MR3.5 - 4.5 ever since. Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017. After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS. Pleural effusion returned within a couple of months, same as before (moderate, left side only). Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved. At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.
Advanced Member
Posted 10 June 2016 - 11:14 AM
Interesting points. We need a lot more info. I'm definitely going to bring this up next onc visit. Scuba, be sure and tell us what Dr. Cortes says. In the meantime, here's a lighthearted question: say suppressing p53 cures your CML, but makes you REALLY OLD REALLY FAST? Would you take it? Hmmmm.
We're all going to die. That is 100% guaranteed. So it's a question of how and when.
Me ... old age in bed with my wife. And she survive me.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
Advanced Member
Posted 10 June 2016 - 11:57 AM
"Unless the drug specifically targets a mutated version of p53 that is. "
That is what the drug does ...
It's when P53 goes 'bad' that we have problems.
I sort of thought it was a mutation but the article didn't specifically state that so I was a little concerned. Thanks Scuba.
Kat, actually it would do the opposite (in theory) as mentioned on the Wiki site; increasing the levels of p53 causes premature aging. I know in reality it would't make you younger but it would be a nice side effect. 
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
Advanced Member
Posted 13 June 2016 - 05:31 AM
That is very interesting about the mutation to p53 as I had read that cancer cells deactivate our immune system in order to survive. This must be where they perform that function. From that link (thanks survenant), I found the below article which discusses the p53 mutation.
http://www.ncbi.nlm....les/PMC3135636/
Now lets all just cross our fingers, hope, pray, whatever, that the drugs work in the Human trials and are not too toxic and kill us.
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
Advanced Member
Posted 13 June 2016 - 10:31 AM
More on the topic:
Preparations have now begun to give the drugs to human patients and it is hoped that those who are not responding well to current therapies could begin the new treatment within 18 months.
Read more at http://www.dailyreco...FkQd4lfYgTLu.99
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
Advanced Member
Posted 13 June 2016 - 01:58 PM
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
Advanced Member
Posted 14 June 2016 - 05:37 AM
Thanks for the link Scuba.
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
Advanced Member
Posted 26 July 2016 - 06:09 AM
This article from the university has a bit more info, a video with some good info and contact info for the scientists involved (no, I don't recommend writing them, I'm sure they are plenty busy).
http://www.gla.ac.uk..._462961_en.html
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
0 members, 1 guests, 0 anonymous users
