"checkpoint reached" -cml
#41
Posted 02 August 2016 - 12:26 AM
So... Dr. Deininger...top notch. What a humble, well-mannered, and knowledgeable man for our disease. I went with high hopes after seeing his name attached to many medical journals, trials and documents online, and left with my questions answered, and not feeling rushed. Very much appreciated his putting up with our tons of questions. It was a privilege to meet with him.
Huntsman- clearly an up and coming world-class treatment center. Clean, elegant, easily accessible, and all-around nice. My favorite that I've visited.
Synopsis (several things were expressed that were echoes of advice from you guys, too, so thanks for your words):
It was Dr. Deininger's opinion that I didn't fail either prior treatment, and rather responded pretty well, detailing that given my spleen size, wbc, basophil and eosinophil count at diagnosis, that I was a high-risk cp'er.
He also stated:
-he's happy with Bosulif as the current tki, as the side effect profile is safer long-term, and said that I likely won't ever be able to attempt cessation.
-pcr's done on the same sample can vary by 5-fold.
-although mmr is optimal, there is no data to suggest any increased O/S over a ccyr maintained for at least 24 months (which predicts a high likelihood of a normal lifespan compared to the general population), although intuition would.
-likely my last pcr's below the ccyr threshold, including the recent .881, are likely the same result, and furthermore, testing monthly in my situation is detecting irrelevant fluctuations due to sampling and testing variables. So 3-month pcr's, from here on.
-he said that transitioning disease from cp to ap, typically will display elevating basophils, promyelocytes and pcr, along with blasts, but typically intervention occurs when pcr climbs above that listed 5-fold range for 2 consecutive tests, and then a full mutation and resistance work up should be performed.
-losing ccyr (over 1%) is when alarms should be ringing, but should be verified with a follow up test, before treatment intervention.
-there is no optimal dosing time for tki's. It is most imperative for continual dosing at the same time, each day.
-Ponatinib, before SCT. Although any residual disease occurring after transplant, often will bare the mutations present before hand, and tki's are used as standard maintenance for 12 or 24 months following any cml SCT.
-he stated there are better statistics which haven't yet been published for SCT, and stated that given my profile, (God forbid) I'd have a 90% to 95% chance of survival with a 10/10 match, with the 10% mortality as a "higher estimation"... But this should only be approached if tki's are exhausted.
-returning to Tasigna would be an option in his mind.
-when asked whether we should watch our two kids closely for blood cancers, it was a "no, this was sporadic".
-when asked about my baby boy on the way, conceived during Gleevec treatment, again, he voiced no concerns, and said that quite a few have fathered healthy babies while on Gleevec.
What an enlightening, validating visit. I'm really glad we have the ability here in the U.S to schedule with different doctors and facilities with out a huge wait, or government agency approval.
08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)
#42
Posted 02 August 2016 - 01:49 AM
#43
Posted 02 August 2016 - 05:20 AM
thatguy, glad he put your mind at ease, I know you were having a tough time worrying that you were going to lose CCyR and such. Most of what he said are things you also hear on these boards (some new info also so thanks!) so there are some very knowledgeable people here too. Just remember, as long as your PCR is not jumping an entire log, you're within the variance of testing.
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
#44
Posted 02 August 2016 - 12:47 PM
Super happy you found Dr. Deininger and put your fears to rest. It makes all the difference in the world to have confidence in your doctor, and to have one that truly listens to you and makes you feel you aren't crazy, dosen't it?
Dx July 2009 on routine physical. WBC 94. Started Gleevec 400 mg Sept 2009. MMR at 2yrs. Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved. Kidney issues developed because of Gleevec. Switched to Sprycel 70 mg in Aug 2011. Above side effects disappeared or improved. Have been MR3.5 - 4.5 ever since. Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017. After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS. Pleural effusion returned within a couple of months, same as before (moderate, left side only). Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved. At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.
#45
Posted 02 August 2016 - 01:14 PM
Yep Like I said I really like Dr. Deininger he always laughs at me and says how do you know all these things....smart girl he says. lol I've asked him before when can we make a baby? he said well that's up to you two, I don't think I should be there. bahahahaha I feel like he has great manners and a good sense of humor at the correct times. I feel very supported by him. he talks me through every question and never rolls his eyes or acts like didn't I just answer that last time? I'm glad you were able to meet with him, I feel very fortunate to have him as my doc.
Diagnosed Oct 2013 Started 600mg of Tasigna on Nov 4th. Lowered dose a few months later to 300mg due to side affects stayed here declining PCR until March 2015 small jump from 0.0072 to 0.0083 scarred my doc into full dose of Tasigna again 600mg(been miserable since) but reached PCRU 06/15/2015(next test) and have been there ever since. Hoping to have another little one. I have the support of my doc to go off anytime, just scared to jump. might go two years PCRU but he said it wont make much of a difference. I just figured I could possibly go into a trial while preggers if I got the two years behind me.
Nov 8th 2017 went off Tasigna
Dec 1st PCRU off TKI
Jan 5th PCR Detected .0625
Feb 1st PCR Detected .7815
Added 8-6 grams Curcumin daily in Feb
March 3rd PCR Detected 3.2646 YIKES!
stopped trying for baby after February reading. will start new TKI march 16th 2017 (Sprycel)
FYI I'm not done trying for my last little one.
#46
Posted 03 August 2016 - 07:48 PM
Yeah, Frogie, he seems like a very likeable guy, and a great doc...It's unfortunate, he didn't just stare calmly and slowly loosen his tie, with a set up like that. Lol. I'm going to be seeing him on a yearly basis from here on, for monitoring.
08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)
#47
Posted 04 August 2016 - 08:00 AM
Diagnosed November 2014 with a WBC of 50+, 92% FISH and 23.5% BCR-ABL; started Gleevec on 12/30/2014. I don't remember all of the test results but my last ones at 18 months are 3.5% FISH and 1.08% BCR-ABL. Not too impressive, but the #'s have been steadily but slowly going down and I'm not bouncing up and down so doc is willing to give it another 6 months before she considers switching to Bosiluf.
Right now, I'm having some issues with shortness of breath and low blood oxygen that is being checked out, so that's another reason for not switching now.
Asides from the puffy eyes, it's hard to tell what might be side effects of Gleevec and what is due to Inflammatory Arthritis but I have a lot of fatigue and pain. Most of the time the pain is tolerable (or maybe I've just gotten used to it) but it does limit my activities along with the breathing issues. I do have Rx for Tramadol and Flexeril for when I really need some relief. I don't think I will ever get used to the fatigue. It's soul crushing at times. I take a multivitamin, high dose of Vit D, B12, folic acid and iron.
#48
Posted 04 August 2016 - 08:51 PM
08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)
#49
Posted 26 August 2016 - 04:36 PM
08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)
#50
Posted 26 August 2016 - 04:57 PM
So 3-month pcr's, from here on.
that didn't last long ... back to every month again? ...
For the benefit of yourself and others please add your CML history into your Signature
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000
2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
Trey's CML Blog - Stopping - The Odds - Stop Studies - Discussion Forum Cessation Study
Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt
#51
Posted 26 August 2016 - 10:01 PM
08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)
#52
Posted 27 August 2016 - 03:19 AM
Great news that your PCR went down with the Bosulif! Hopefully the side effects will taper off a bit as your body adjusts to the new medication.
3/23/2016 Dx PCR 93.4399% IS, FISH 87%
3/30/16 Sprycel 100mg
4/15/2016 liver toxicity and a brief stint on Tasigna 600mg book-ended by drug breaks
6/6/2016 resumed Sprycel at 50 mg increased to 70 one month later followed by 100mg
6/17/2016 FISH Test 2%
8/22/2016 PCR 0.0035% IS
11/7/2016 PCRU
12/29/2016 PCRU
4/5/2017 PCRU
6/28/2017 PCRU
10/26/2017 PCRU
#53
Posted 27 August 2016 - 12:19 PM
TG,
One of your biggest issues was too many PCRs too close together showing a misperception of lack of fast enough response. In reality you simply had the standard Tasigna plateau, and one random small blip upward. Although the switch to Bosulif was just fine (no reason is needed to switch drugs) you could also do well on Tasigna long term. There is no reason to worry about your future. Look forward to the birth of your baby boy and seeing him grow up.
#54
Posted 30 August 2016 - 03:45 PM
My Dr. has since corresponded with Deininger and I believe may have gained/reevaluated some valuable CML disease/treatment management expectations. Hopefully future patients will benefit as a result. They have a tough job, and the amount of knowledge they have to learn and retain is tremendous. Hopefully this was a beneficial series of events for many, including readers on here.
The boy's coming in 2 weeks and at check up last week was already 7 lb 4 Oz they estimate...bigger than his sister was at birth. Lol. Poor Mom.
08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)
#55
Posted 10 September 2016 - 02:18 AM
I think I just hit a major milestone, but I am wondering if there is a possibility of a bad test so I am trying not to get too excited. On August 22nd I took my first PCR since diagnosis back in March and the results came back pretty amazing. My value went to 0.0035% IS. I was tempted to ask for another PCR to confirm it, but I think I can wait a few months and hope that it was accurate. Has anyone else experienced such a rapid decline in their PCR values? Has anyone seen a very good number like this only to discover that subsequent tests were off by a log or more? I have to say I was very surprised by the result. I was hoping to see a zero to the left of decimal point and had no expectation of any on the other side based on discussions mentioning a plateau.
3/23/2016 Dx PCR 93.4399% IS, FISH 87%
3/30/16 Sprycel 100mg
4/15/2016 liver toxicity and a brief stint on Tasigna 600mg book-ended by drug breaks
6/6/2016 resumed Sprycel at 50 mg increased to 70 one month later followed by 100mg
6/17/2016 FISH Test 2%
8/22/2016 PCR 0.0035% IS
11/7/2016 PCRU
12/29/2016 PCRU
4/5/2017 PCRU
6/28/2017 PCRU
10/26/2017 PCRU
#56
Posted 11 September 2016 - 10:29 PM
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#57
Posted 13 September 2016 - 07:51 AM
Thank you Gail, I hope that in my case the number is accurate and my experience has been similar to yours. Initially I was given the choice between Gleevec and Sprycel and I opted for the Sprycel because the doctor told me simply that it was better. Based on what has been a good response so far (despite the initial liver issues) and also on your experience, it seems that it was the right choice. I will feel a little more at ease when I see a second PCR that has a nice low value like this. I think I will ask for another one at my next visit to the hospital.
3/23/2016 Dx PCR 93.4399% IS, FISH 87%
3/30/16 Sprycel 100mg
4/15/2016 liver toxicity and a brief stint on Tasigna 600mg book-ended by drug breaks
6/6/2016 resumed Sprycel at 50 mg increased to 70 one month later followed by 100mg
6/17/2016 FISH Test 2%
8/22/2016 PCR 0.0035% IS
11/7/2016 PCRU
12/29/2016 PCRU
4/5/2017 PCRU
6/28/2017 PCRU
10/26/2017 PCRU
#58
Posted 15 September 2016 - 05:50 PM
I think I just hit a major milestone, but I am wondering if there is a possibility of a bad test so I am trying not to get too excited. On August 22nd I took my first PCR since diagnosis back in March and the results came back pretty amazing. My value went to 0.0035% IS. I was tempted to ask for another PCR to confirm it, but I think I can wait a few months and hope that it was accurate. Has anyone else experienced such a rapid decline in their PCR values? Has anyone seen a very good number like this only to discover that subsequent tests were off by a log or more? I have to say I was very surprised by the result. I was hoping to see a zero to the left of decimal point and had no expectation of any on the other side based on discussions mentioning a plateau.
That's awesome, man. It's likely accurate. My best advice, based on my trek so far: try your best not to think about the disease, other than taking your meds religiously, and following warnings for what reduces med absorption.....
Even if not accurate, you're likely at a very low level for it to degrade that low, and still be viable for the lab. Good luck, buddy!
08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)
#59
Posted 15 September 2016 - 08:57 PM
Hopefully it is accurate and if it is you could be a good candidate for trying cessation after two years PCRU.I think I just hit a major milestone, but I am wondering if there is a possibility of a bad test so I am trying not to get too excited. On August 22nd I took my first PCR since diagnosis back in March and the results came back pretty amazing. My value went to 0.0035% IS. I was tempted to ask for another PCR to confirm it, but I think I can wait a few months and hope that it was accurate. Has anyone else experienced such a rapid decline in their PCR values? Has anyone seen a very good number like this only to discover that subsequent tests were off by a log or more? I have to say I was very surprised by the result. I was hoping to see a zero to the left of decimal point and had no expectation of any on the other side based on discussions mentioning a plateau.
#60
Posted 18 November 2016 - 06:26 PM
-all other counts normal
-no perceived side effects from Bosulif, dosing ease destroys Tasigna.
-have a healthy new baby boy, 2 mos. old.
Attached Files
08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)
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