6 replies to this topic

[jlegakis]

With all the TKI`S out there is a stem cell transplant the end of the road? I am 67 and do not think I`ll ever need one but what are the so-called odds of having to have a transplant with so many new drugs out there?

[mike43147]

Everybody's situation is different.  Mutations to their CML and how they handle the TKI side effects.  I went through 5 different TKI's before my stem cell transplant Nov 2015.  I had 2 different mutations, neither being a common mutation.  In my situation the SCT was/is the end of the road.  The good news is I haven't taken a TKI in 7 months and presently am only taking 1 antiviral drug post transplant.  I am CML free and hope to remain that way until I leave this Earth playing golf and drinking good liquor.  Trey would probably have the statistics.  Maybe he know the percentages.     

[PJM]

Whereas stem cell transplants were first line treatments prior to the development of TKIs, they are now used only after a patient has tried and failed most or all of the current TKIs available. I, like Mike43147, tried multiple TKIs and failed all of them.  I had a stem cell transplant in December 2015 and it was the last resort. I was advised to proceed while still in relatively good health and while I remained in chronic phase. I still have small but detectable BCR/ABL and TKI therapy is being used in my case to reduce what is remaining.  The use of TKIs post transplant is viewed a viable treatment plan which has worked to reduce the amount of CML in some patients and hopefully will do so in mine   I believe there are threads on this board that address the current place of stem cell transplants in the overall treatment of CML. It remains the only definitive cure for CML.  Stem cell transplants continue to  provide a vital option for the small percentage of patients who, unfortunately,  do not benefit from TKI therapy.  

[r06ue1]

Unless you absolutely, positively have to have one, avoid it at all costs.  I had brought it up to my Oncologist early after my diagnosis and he mentioned the odds and I didn't like the sound of it after hearing that.

[hannibellemo]

Congratulations, Mike! Excellent news, all best wishes for continuing success post transplant.

[hannibellemo]

You, too, Pam! Just read your post. So glad to hear how you are doing. I remember you had such a rough time before going into transplant.

[thatguy]

Glad to hear of your successes!