Advanced Member
Posted 04 May 2016 - 01:14 PM
I know that the manufacturer states it can be taken with or without so I assume the level of effectiveness would not be affected much if at all either way. I am just curious though if taking it with a meal would increase absorption and possibly its effectiveness if it were taken with a large meal when compared to an empty stomach.
Diagnosed Age: 28
Diagnosed Date: Oct-20-2015
0-27 Months Rx: Sprycel 100mg
Current Rx: Sprycel 50mg
0 Month PCR = 87%
3 Month PCR = 1.2%
6 Month PCR = 0.64%
9 Month PCR = 0.26%
12 Month PCR = 0.21%
15 Month PCR = 0.15%
18 Month PCR = 0.11%
21 Month PCR = 0.051%
24 Month PCR = 0.047%
27 Month PCR = ?.???%
Advanced Member
Posted 04 May 2016 - 01:29 PM
Makes no difference.
I take sprycel, however, at bedtime, which is usually several hours after the last meal of the day.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
Advanced Member
Posted 04 May 2016 - 01:31 PM
Hi John,
I don't have any scientific data on this but I did see improvements in my PCR readings around the time I switched over to taking my Sprycel in the morning and right after breakfast. I also try to include some orange juice which is acidic and may help with Sprycel absorption. Again, I am not sure this helped on a molecular level but my thinking is that taking it in the morning when the body is metabolizing food for the day may be useful. I would say that I tend to notice some mild nausea usually a few hours later (after coffee) so I try to be sure to keep water on hand top hydrate and this helps.
Take care,
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