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#1 r06ue1

r06ue1

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Posted 04 May 2016 - 06:01 AM

https://www.cml-foun...php/icmlf-forum

 

Found this site very interesting, shows how Oncologists make decisions on what's best for their patient and has a lot of other interesting information that many of us never really see including rare cases.  

 

Found this very interesting:  

 

 

 patients who take <90% of their dose have 0% chance of achieving undetectable transcript levels. Missing 10% of the dose is not much, it is only 3 days per month. 

 

Never missed a dose and never plan to.   :)

 

FYI, some of the information is scary so if you are prone to giving into fear, I would suggest avoiding the link.


08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%

 

 

Taking Imatinib 400 mg


#2 Gail's

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Posted 06 May 2016 - 01:58 PM

Interesting and gave me new topic to research, that of CML and CNS involvement. The case described had headaches as its presentation and I'm curious about how often this happens, if it's considered metastasis and sounds like prognosis not great. Happily dasatinib does cross the blood brain barrier and that's good!
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088




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