Posted 29 April 2016 - 03:18 PM
I just got results of my latest PCR at around ~11 months after starting Gleevec 400mg. They are 0.183 compared to 0.16 3 months ago. It is a slight rise which is concerning. The doctor has ordered a retest and a mutation test to determine next steps.
I guess we will either have to increase Gleevec or switch to Sprycel. Is it worth continuing Gleevec at 400mg for 3 more months? I have the side effects more or less under control and am wary to switch.
maxim, a single test plateau is not a wall, and there is essentially little difference between 0.16 and 0.183, especially considering the possible inaccuracies in test results; it's certainly nothing to panic about.
For the benefit of yourself and others please add your CML history into your Signature
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000
2018 01/16 TFR PCR result pending... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
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