5 replies to this topic

[TeddyB]

http://journals.lww....spx?PostID=1411

 

 

"The potential ability for pacritinib to eradicate therapy resistant leukemia stem cells in relapse AML as a single-agent, as well as eliminate self-renewing stem cells in CML, when used in combination with standard of care therapy, demonstrates that targeting niche-dependent signaling with pacritinib could represent a new approach to treating patients with refractory acute myeloid leukemia and blast crisis of CML," said Balaian.

[Trey]

The US FDA has placed a full clinical hold on Pacritinib due to deaths and severe arterial and cardiac issues. 

 

"...all patients currently on pacritinib must discontinue pacritinib immediately and no patients can be enrolled or start pacritinib as initial or crossover treatment."

http://www.curetoday...h.MosO5bjb.dpuf

 

In another matter, this keeps the name "shartinib" available for future use.  Wonder when some company will jump on that. 

[rcase13]

While Pacritinib is obviously bad isn't it the first to attack stem cell? Maybe version 2.0 will work better.

[Trey]

Many, many agents have been tried and failed.  The trick is to find something that kills leukemic stem cells but does not kill the host.  That is the nearly impossible task, which is why nothing has succeeded so far.   Actually, gasoline works very well against stem cells.  But the host does not survive.  Maybe Pacritinib can be used as fuel.

[rcase13]

Maybe we should just have weekly bone marrow biopsy's. Eventually they will dig out all the bad stem cells right? We just need volunteers for a trial...

[TeddyB]

Maybe we should just have weekly bone marrow biopsy's. Eventually they will dig out all the bad stem cells right? We just need volunteers for a trial...

 

Ouch, that sounds horrible