Posted 27 April 2016 - 03:30 PM
Thanks Trey! You always make me laugh!
Guess, I never paid much attention to the different breakpoints and mainly focused on the total PCR result. It would be nice to know if one is more dangerous than the other, like most evil twins. Not that there's anything we could do about it, but sometimes the information is in-powering. I like to visualize my TKI beating up the evil ones to get them in control. Maybe now, I'll name them...something appropriate for the bullies they are. I like Chucky for the b3a2...I'll have to think of a name for the b2a2, since it's on the run.
Don't most people with CML have two or more breakpoints on the chromosomes? My results describe the b2a2 and b3a2 as being major breakpoints and e1a2 as a minor breakpoint. Does major or minor mean anything in regards to burden of leukemia? Can the margin of error be in each breakpoint or is it calculated for the total?
Dx - 05/2011; PCR: 15.04; Fish: 87% Slow responder due to pancytopenia. Current - Bosulif - Nov: 2012, Mar 2016 lowered to 300 mg. 07/16 back to 400 mg. Clinical trial drug, Promacta, Feb 2013, for low Platelets.
CyCR - Aug 2014, Positive for 1 chromosome Sep 2015. PCR: 12.77 in Oct, 2012 to 0.04 (MDA) in Mar, 2016. 4/2016 - 0.126 (Local lab (IS); 05/2016 - 0.195 (local); 6/2016 - 0.07 (MDA); 7/2016 - 0.03 (local) 9/13/2016 - 0.16 (MDA); 9/26/2016 - 0.31 (MDA); 11/2016 - 0.012 (local); 01/2017 - 0.24 (MDA); 04/2017 - 0.09 (MDA); Cytogenetics show der(1:7)(q10;p10)7 chromosome mutation. Repeat of Sep 2015. PCR - 6/2017- 0.035 (local); 10/2017- 0.02 (MDA)