What i found interesting was of course this sentence:
"Patients who undergo transplantation for chronic myelogenous leukemia may also fit the trial's eligibility criteria."
https://www.fredhutc...t-leukemia.html
JAL: Just another link, interesting though. Tailoring immune cells to target leukemia
Started by
TeddyB
, Apr 23 2016 12:19 PM
7 replies to this topic
#2
r06ue1
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Posted 26 April 2016 - 05:59 AM
This is what Sean Parker is putting $250 million into researching.
Hopefully the transplant requirement can be taken out of the equation at some point for those of us permanently in chronic phase.
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
#3
Red Cross Kirk
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Posted 26 April 2016 - 09:38 AM
I have a lot of questions after reading this.
Does transplantation have anything to do with the treatment described?
Do CML cells express the WT1 molecule or something similar?
How expensive is this new therapy likely to be if it becomes more commonplace?
Is it a good thing that TKIs are so expensive? Being that it will cause the insurance companies to look favorably on immunotherapy as a more cost effective treatment for CML? Or will the availability of generic imatinib cause them to drag their heels?
How does a treatment move from experimental to recommended therapy status? Who decides?
Do we have reason to be excited about this?!
Kirk
09/2012 p210 transcript 118.7% IS @ Dx, begin Gleevec 400mg/day
12/2012 3.59% & bone marrow biopsy - no residual myeloproliferative features but detected 1/20 metaphases containing the Philadelphia chromosome
2013 0.914%, 0.434%, 0.412%
10/2013 0.360% & bone marrow biopsy - normal male karyotype with no evidence of a clonal cytogenetic abnormaltiy
2014 0.174%, 0.088%, 0.064%
2015 0.049%, decrease to 200mg/day, 0.035%, 0.061%, 0.028%
2016 0.041%, 0.039%, 0.025%
2017 0.029%, 0.039%, 0.070%, 0.088%
#4
Red Cross Kirk
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Posted 26 April 2016 - 10:35 AM
I found a very general answer as to the cost of immunotherapy in this article: http://www.fredhutch...herapy.html#six
Here's a snippet:
"This is among the most complicated technologies that have been developed. It would be no big surprise, particularly as the technology is being refined and improved, if initial costs will be extraordinarily high," Dr. Gary Lyman said. Lyman is a public health researcher, breast cancer oncologist and co-director of the Hutchinson Institute for Cancer Outcomes Research.
Just as the cost of genome sequencing plummeted from $100 million just 15 years ago to less than $1,000 today, Lyman anticipates that the costs of the technologies involved in cellular immunotherapies will drop substantially over time as well.
Kirk
09/2012 p210 transcript 118.7% IS @ Dx, begin Gleevec 400mg/day
12/2012 3.59% & bone marrow biopsy - no residual myeloproliferative features but detected 1/20 metaphases containing the Philadelphia chromosome
2013 0.914%, 0.434%, 0.412%
10/2013 0.360% & bone marrow biopsy - normal male karyotype with no evidence of a clonal cytogenetic abnormaltiy
2014 0.174%, 0.088%, 0.064%
2015 0.049%, decrease to 200mg/day, 0.035%, 0.061%, 0.028%
2016 0.041%, 0.039%, 0.025%
2017 0.029%, 0.039%, 0.070%, 0.088%
#5
r06ue1
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Posted 26 April 2016 - 11:46 AM
If you can cure someone in one shot versus them taking a drug all their life, seems like insurance companies would be on board, but you have to look a lot deeper into how they get to their decisions and who it is (the board) that is making those decisions.
Also, what if a cure for cancer came out today, could you imagine the catastrophic affect that would have on the global economy? Look at all of the money being made today around cancer, in my city alone there are many brand new, beautiful hospitals 100% dedicated to cancer, nothing else. All of those buildings and everyone employed there would be pretty useless if your local family doctor could give you a shot to cure your problem. I bet there are trillions of dollars globally that are dependent on us being sick.
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
#6
Gail's
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Posted 03 May 2016 - 12:16 AM
So this will date me, but did anyone else think the dr from the article looks like Doc in "Back to the Future?" Both free thinkers, for sure!
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#7
r06ue1
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Posted 03 May 2016 - 05:28 AM
Maybe he owns a Delorean? 
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
#8
Gail's
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Posted 06 May 2016 - 02:23 PM
"great scot, r06ue1, I think you're right!"
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
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