Posted 21 April 2016 - 12:11 PM
I'm bummed too. A year ago I reduced from Gleevec 400mg to 200mg per day because I was tired of the foot cramps and small hemorrhages on my hands. Before that my PCR had been going down every time. My March 2015 PCR was .045 and this March it was .041. I recently asked my onc if maybe I should go up to 300mg per day or maybe change meds. He hasn't responded yet. I guess I should just be happy to be where I am. I don't feel like a turtle anymore, I feel like a slug.
Gleevec is best taken with food; avoid "fatty foods" to improve absorption. Acidics, such as fruit juice, improve absorption. I take a vitamin C with dinner and take Gleevec, an hour, or so, after dinner, with fruit juice. Works for me.
For the benefit of yourself and others please add your CML history into your Signature
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000
2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
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