Since December I've been on two drug breaks for plural effusions caused by Sprycel. One was for three weeks around the holiday which was fantastic because I had unlimited energy to get everything done.
The next one was for four weeks after trying to reduce the dose to 70mg. During my first break, my pcr remained negative but after only a week during my second break my pcr bounced up to .014. I know low but in my mind I was terrified the number would skyrocket during the next three weeks. I made a change to Gleevec 400mg and started on Friday April 1st. Went to my onc last Thursday April 7th and I'm back to negative according to my results yesterday. Whether the one test was not accurate I don't know.
The other thing I wanted to let everyone know is about thyroid. I had a thyroidectomy right after being diagnosed with CML in Sept. 2014. After a few months of getting me to a suppressed level, I maintained the same level. During my second drug break, my blood pressure rose, and I was having heart palpitations. I called my endocrinologist and she had me go in to check my levels. I went hyperthyroid with a tsh level of .044 so she adjusted my meds. Man, I felt like crap.
I mentioned all this to the pharmacy at my onc's office (Northwestern). He said they see Gleevec effect synthroid's effectiveness the most, but being off Sprycel must have made my synthroid more effective hence hyperthyroid. Just some information on those that take synthroid and are on a tki. Especially as more people are trying to go tki free or lower dosages.