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FYI on second gen' TKI's and liver function

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#1 scuba


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Posted 12 March 2016 - 01:03 PM



Dasatinib, Nilotinib Safe and Effective in CML Patients With Renal, Liver Dysfunction

Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein


Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.


2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"

#2 pammartin


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Posted 12 March 2016 - 09:47 PM

My liver enzymes went up quite a bit while on Sprycel.  Enough to order additional blood work.  Nothing remarkable found.  When I stopped Sprycel they returned to normal range. 


I am sold on the idea although there are common side effects for all TKIs, there are rarely two with the exact same ones.  Then when you add in age, overall health, and lifestyle, it just mixes the pot a little more.

#3 hannibellemo


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Posted 15 March 2016 - 06:17 AM



My liver enzymes went up (1500 ALT and 1300 AST) after 9 months on Gleevec necessitating a switch to Sprycel after they returned to normal. An ultrasound showed no damage to liver and I felt fine.


I was off all meds for 7 weeks and never had a liver enzyme blip on Sprycel. Couldn't agree with you more about common side effects being different for everyone.



"You can't change the direction of the wind but you can adjust your sails."

DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>

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