When to be concerned about rising pcr
Posted 06 February 2016 - 10:42 PM
Posted 07 February 2016 - 07:36 AM
This should give you a good idea of where your husband should be at this point and what to discuss with him and his doctor if he isn't there or if you are afraid he is losing response.
Just checked the link and it doesn't open directly to the PDF. Click on PDF second from top.
If those percentages are on the international scale he does appear to have lost Major Molecular Response (MMR = .1%) but remains
in Complete Cytogenic Response (CCyR = 1%).
I always say go with your gut instinct, If you (and he) are concerned you should be having this conversation with his onc.
Edited by hannibellemo, 07 February 2016 - 07:38 AM.
"You can't change the direction of the wind but you can adjust your sails."
DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>
Posted 07 February 2016 - 07:53 AM
first of all, i'll check if his adherence to therapy is ok and them i'll check for interactions (drugs and food). maybe a re-test in a month time is a good idea. good luck!
Posted 07 February 2016 - 11:05 AM
Lucas, thanks for the reply! I know his adherence is great. He is type A about taking his meds and avoiding food around that time. As far as food interactions, are there things that can interact with tasigna even outside of that three hour window of taking it on an empty stomach? I know about grapefruit but not anything else.
Also, he was tested for mutations back when he failed sprycel and had none. Can that change in a short amount of time? Trying not to worry...
Posted 07 February 2016 - 11:59 AM
The first thing to understand is that PCR results are not nearly as precise as the number of digits in the result would imply. So your husband's results are not such a wide variation. Also, Tasigna response tends to stall out into a plateau which can last for a while. He is likely in such a plateau. Kinase mutations show up as sharp rises, and he does not show signs of that. The fatigue is multifaceted and not normally caused by the disease itself at his levels of response. Overall, given his history with the other drugs, he is doing fine. We all want better, but sometimes "just fine" is what we get.
Posted 07 February 2016 - 05:23 PM
10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)
Posted 08 February 2016 - 04:50 PM
Rcase13, I'm not sure the answer to your question. But I have heard of quite a few people having liver issues on bosulif. My husband probably could have tried bosulif again on a lower dose but we didn't push it because it made him so sick. I was glad he was off of it. His doctor thought tasigna was a better option.
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