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Tasigna and its side effects...

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#21 chriskuo


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Posted 15 March 2016 - 03:36 AM

If you have diabetes, switching to another TKI may be advisable.  Tasigna often causes hyperglucemia.

#22 steelpony5555


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Posted 19 March 2016 - 09:59 AM

For those with Neuropathy, I finally went to a podiatrist and he prescribed an anti depressant Cymbalta for it????  Strange, but yes it works.  It has reduced the pain and stiffness in my feet by 50%.  I go back to see him in 2 weeks and guess we'll see what he can do to reduce it further...

#23 rcase13


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Posted 29 September 2016 - 12:32 PM

Bringing this thread back. Initially when I started Tasigna the first couple days/weeks I had powerful nausea. It went away after a couple weeks. That was two years ago. Now all of a sudden i have nausea again. Has anyone had this happen? Almost two years with no nausea. All my numbers are good and I am undetectable. Why would I all of a sudden get nausea again? I also around the same time started to get the itchy head again.


Nothing has changed with my dosage. I take the normal 600mg per day. My diet is the same as well.

10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)

01/02/2015 0.06% Tasigna 600mg
04/08/2015 0.01% Tasigna 600mg
07/01/2015 0.01% Tasigna 600mg
10/05/2015 0.02% Tasigna 600mg
01/04/2016 0.01% Tasigna 600mg
04/04/2016 PCRU Tasigna 600mg
07/18/2016 PCRU Tasigna 600mg
10/12/2016 PCRU Tasigna 600mg
01/09/2017 PCRU Tasigna 600mg
04/12/2017 PCRU Tasigna 600mg
10/16/2017 PCRU Tasigna 600mg
01/15/2018 PCRU Tasigna 600mg


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#24 gerry


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Posted 29 September 2016 - 04:59 PM

Not sure about Tasigna, but with the Gleevec you could cycle through the same side effect every so often. The only good thing about it was you knew what to expect and how to maybe treat it.

#25 tiredblood


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Posted 29 September 2016 - 06:49 PM

I'm nearing the three year mark on Tasigna, now on 1/2 the dose, and nothing surprises me anymore. Weird stuff happens that I attribute to the medication, yet unproven in the clinical world. Nevertheless, I'm the one taking it and the one experiencing stuff, I'm my own advocate.

#26 Buzzm1


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Posted 29 September 2016 - 07:24 PM

It has been my experience that lowering the TKI dose helps lessen, but doesn't eliminate, the probability of side-effects.  I'm expecting to experience side-effects even when, and if, I discontinue Gleevec.  I'll term it collateral damage.  

For the benefit of yourself and others please add your CML history into your Signature


02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive


2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17


At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  


In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  


longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.


Cumulative Gleevec dosage estimated at 830 grams


Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  


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